Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.

Research Abstract

As part of a collaborative program to further explore the chemical biology of the RNAP-inhibitory activity of the salinamides, we examined in more detail the extract and semi-purified fractions from the recultivation of Streptomyces sp. CNB-091 and report here the isolation of a new salinamide analog, salinamide F with the previously described salinamides A and B and minor amounts of salinamides C–E. salinamide F, which, like salinamide A, also possesses significant RNAP-inhibitory and antibacterial activity.

Research Keywords

salinamide F