1. El-Moghazy, S. M.; Mohamed, M. A. A; Farag, A. E. and Gouda, A. M., “Synthesis and antitumor activity of some 5H-pyrrolizine, pyrimido[5,4-a]pyrrolizine, pyrimido[4,5-b]pyrrolizine derivatives”, S.P.J., 17, 3-18(2009).

Research Abstract

Seven new series of condensed pyrrolizine derivatives of anticipated antitumor activity have been synthesized. Comprises ethyl-1-cyano-3-phenylcarbamoyl-6,7-dihydro-5Hpyrrolizin- 2-yl-carbamate, 2,4-dioxo-1H-pyrimido[4,5-b]pyrrolizine-9-carbonitrile, 1- cyano-2-(3-substituted ureido)-3N-phenyl-6,7-dihydro-pyrrolizine-3-carboxamide, 3- (alkyl / phenyl)-4-imino-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido [5,4- a]pyrrolizine-9-carboxamide , 4-amino-3-(alkyl / phenyl)-2-oxo-2,3,4,5,6,7-hexahydro- 1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide, of 2-amino-3N-phenyl-6,7-dihydro- 5H-pyrrolizine-1,3-dicarboxamide and 4-oxo-9N-phenyl-4, 5,6,7-tetrahydro-3Hpyrimido[ 5,4-a]pyrrolizin-9-carboxamide derivatives. Eleven were screened for their in vitro antitumor activity and ten compounds proved to possess moderate to weak activities.

Research Keywords

Pyrrolizine, pyrimido[4,5-b]pyrrolizine, pyrimido[5,4-a]-pyrrolizine, anticancer, probit analysis