Design,synthesisandBiologicalEvaluationofNovel Diaryl-heterocyclicderivativesasPotentialAnalgesics andAnti-inflammatoryAgents

Research Abstract

In the present work, design and synthesis of several substituted diarylthiazole VIIIa,b and IXa-h, diarylimidazole XIIa,b and XIIIa-h, thiazolidinone XVI-XX and XXIV-XXVIII were discussed. The rational for these compounds was discussed. Characterization of the chemical structure of the new compounds was done using spectral and elemental analyses. Evaluation of the anti-inflammatory and analgesic activity of the new compounds was performed by determination of the percentage of inhibition of edema for anti-inflammatory activity and number of writhing for analgesic activity. The most potent diarylthiazole compounds were VIIIa,b with IC50 of 4.21 µM and 4.56 µM against COX-1 respectively. The most potent diarylimidazole compounds were XIIa,b with IC50 of 6.32 and 7.09 µM against COX-1 respectively

Research Keywords

Design,synthesisandBiologicalEvaluationofNovel Diaryl-heterocyclicderivativesasPotentialAnalgesics andAnti-inflammatoryAgents