A Pharmaceutical Study on Thioctic Acid

Research Abstract

Abstract Thioctic acid is a well known drug used for the treatment of both autonomic and peripheral diabetic neuropathy. It is a natural antioxidant which neutralizes free radicals including oxygen radicals and ionized metals. Thioctic acid (TA) is absorbed via the stomach and gut, and can easily be supplemented orally. It is well known that the flowability is one of the most important factors in drug development. Inadequate flow properties of solids can cause serious problems during pharmaceutical unit operations (e.g. compression, filling, conveying). Of particular interest is segregation, which can be very complex in terms of its cause and compounding. Powder flow is most frequently thought of as relevant to formulation development, and it was attempted to correlate any one of a number of measures of powder flow to the manufacturing properties in formulation. Therefore the aim of this work is to overcome the poor flowability of thioctic acid in order to formulate it as compressed tablets with low production costs, compatible excipients and improved quality and bioavailability. Thus the work in this thesis is divided into four chapters Chapter I: Preformulation Study of Thioctic acid Chapter II: Formulation and Evaluation of Thioctic acid Tablets. Chapter III: Stability Study of the Selected Thioctic acid Tablets. Chapter IV: Bioequivalence Study of the Selected Thioctic acid Tablets.

Research Keywords

A Pharmaceutical Study on Thioctic Acid