The role of certain factor in treatment of Acute Hepatic Failure induced by D–GalN/LPS mediated by its antioxidant effects.

Research Abstract

Acute Hepatic Failure is the most serious liver disease worldwide and caused by D-GalN/LPS administration . Aim: The aim of this study is to assess the antioxidant effects of certain factor in rat liver treated with D-GalN/LPS. Methods: Thirty male Wistar rats were randomized into three groups of 10 animals. Normal control treated with saline, D-GalN/LPS group treated with (D-GalN (300 mg/kg) + LPS (10 μg/kg), treatment group treated with a certain factor (100 mg/kg) + (D-GalN (300 mg/kg) + LPS (10 μg/kg)). Results: We showed that D-GalN/LPS significantly increase the lipid peroxidation and ALT liver enzyme activity, whereas significantly decrease the antioxidant (GSH and CAT). We also observed a statistically significant decrease in MDA and ALT level with the certain factor treated animals, also it restores the depletion in GSH and CAT. Conclusion: In conclusion, this factor act as a powerful hepatoprotectant

Research Keywords

hepatotoxicity