Formulation and Availability of Certain Anti-inflammatory Drugs from Liquid Suppository

Research Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are used mainly for treatment of Inflammation. Diclofenac Sodium is one of the very effective anti-rheumatic drugs. However, it is reported to cause GIT irritation, has rapid absorption and elimination. Therefore, its administration as a liquid suppository new dosage form will reduce its GIT side effects, provide effective blood levels for reasonably long time. This also applies to the drug indomethacin, which causes serious inflammation of the gut wall and is exposed to rapid metabolism of the liver and has a short half-life. The objective of this thesis is to design a new delivery mode by means of liquid cones based on the thermal transformation of the solid image using a group of surface active substances (POLYXMAR 407 and POLYSMAR 188) by 15 to 15% by weight and 15 to 20% by weight with some polymers Talate helps in mucosal adhesion such as sodium, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and ionic concentration control materials such as sodium chloride salt and sodium phosphate

Research Keywords

Formulation and Availability of Certain Anti-inflammatory Drugs from Liquid Suppository