Modeling, Optimization, and In Vitro Corneal Permeation of Chitosan-Lomefloxacin HCl Nanosuspension Intended for Ophthalmic Delivery

Research Abstract

lomefloxacin HCl with chitosan was achieved not only through crosslinking and added antibacterial effects of chitosan but also through optimized nanosized particles. Lomefloxacin HCl nanosuspension with good entrapment efficiency, small particle size, and zeta potential was obtained through modeling and optimization of the formulation parameters. The optimized nanosuspension can prolong drug release, increase drug permeation, increase adherence to eye tissues, and hence maximize the ocular antimicrobial effects of the drug. Chitosan played the major role in the enhancement of both antimicrobial and transcorneal permeation of LF

Research Keywords

Antibacterial activity . Chitosan . Ionic gelation . Lomefloxacin HCl . Nanosuspension optimization . Transcorneal permeation