Mustafa A. AbdEllraheim, Amira M. AboYoussef, Hany A. Omar, Hekma A. AbdEllatif. Angiotensin inhibitors potentiate the hypoglycemic and antioxidant effects of gliclazide in rats. International Journal of Pharmaceutical Sciences Review and Research, March 2015, 31 (1) 14-847

Research Abstract

Diabetes mellitus and hypertension are major public health problems which resulting in significant morbidity and mortality. In the present study, we evaluated the effect of concurrent administration of one of gliclazide with captopril or losartan on its antidiabetic activity and the oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Hyperglycemia was induced in rates by the injection of STZ (50 mg/kg i.p.). Diabetic animals received gliclazide (10 mg/kg p.o.), captopril (10 mg/kg p.o.) or losartan (5 mg/kg, p.o.) as single treatments or in combinations. In addition, the combination effect was confirmed by the use of in vitro pancreatic islets. The combination effects were assessed by the measurement of serum glucose level, serum insulin level, liver glycogen content and oxidative stress parameters. In vivo and in vitro results showed that the combination of captopril or losartan with gliclazide results in significant decrease in serum glucose, increase in serum insulin, increase liver glycogen content and improvement of oxidative stress parameters. Combination of captopril or losartan with gliclazide potentiated its effect on lowering the serum glucose level of diabetic rats. This effect highlights the importance of dose lowering consideration upon combining these medications.

Research Keywords

Diabetes; Gliclazide; Captopril; Losartan; Serum glucose; Oxidative stress.