Basic Informations
C.V
- Education
3/2011-
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PhD Degree in Pharmaceutical Sciences (Pharmacognosy), Beni Suef University, Beni Suef, Egypt
- A data collection fellowship (2008-2010) in the School of Pharmacy, University of Mississippi, University, MS 38677, USA under supervision of Prof Dr. Daneel Ferreira, chair of the department of pharmacognosy and Prof Dr. Jordan K. Zjawiony
- Entitled: “Comparative phytochemical and biological study of certain plants of family Cycadaceae cultivated in Egypt”.
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7/2007
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Master Degree in pharmaceutical Sciences (Pharmacognosy) Cairo university, Cairo, Egypt.
- Entitled: ‘Pharmacognostical study of Hordeum vulgare L. family Graminae growing in Egypt’
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6/2000
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Bachelor of Pharmaceutical Sciences, Cairo university, Beni Suef branch, Beni Suef , Egypt
- Grade; Excellent with Honor
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- Professional Experience
2.1. Positions occupied:
Year
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Position
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Oct 2013 -
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IT unit Executive Manager, Faculty of Pharmacy, Beni Suef University, Beni suef, Egypt
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2011 -
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Lecturer of Pharmacognosy Faculty of Pharmacy, Beni Suef University, Beni suef, Egypt
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2011- 2012 and 2014-2015
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Part-time lecturer in Nahda University in Beni Suef)
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2007- 2011
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Assistant lecturer of Pharmacognosy, Faculty of Pharmacy, Beni Suef University, Beni suef, Egypt
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2000- 2007
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Demonstrator of Pharmacognosy, Faculty of Pharmacy, Beni Suef University, Beni suef, Egypt
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2.2. Teaching Experience
2.2.1. Teaching undergraduate courses
- Botany and medicinal plants and Pharmacognosy-I for first year students
- Phytochemistry-1 and Quality Control of herbal medicine for third year students
- Pharmacognosy-III for second year students
- Phytotherapy for fourth year students
- HPLC for fifth year students
3.3.2. Teaching postgraduate courses
1- Advanced chromatographic techniques
2- Biosynthesis of natural products
3- Application of spectroscopic techniques in the structure elucidation of natural products
2.3. Research Experience:
v A member of the NMR technical committee; have an excellent expertise in NMR data acquisition, processing using Topspin Bruker’s software and NMR data interpretation as well as acquiring and processing the data using MestRec, MestreNova, ACD lab.
v Well proven practical skills in planning and executing isolation and structure elucidation of isolated metabolites from natural sources
v Expertise in chromatographic techniques such as HPLC (High Performance Liquid Chromatography, analytical and preparative), LCMS, partition chromatography, VLC and other chromatographic Techniques for the isolation of pure bioactive secondary metabolites belonging to different chemical classes especially flavonoids, biflavonoids, flavonoids glycosides, triterpines, sterols, alkaloids….etc.
v Excellent macroscopical and microscopical examination of medicinal plants.
v Good written and communication skills and the ability to work well in a collaborative/ industrial environments
v Passed international TOEFL exam with 82 IBT (2008)
v In vivo biological models (anti-inflammatory, hepatoprotective) and measuring blood parameters
v Softwares: Excellent computer knowledge, MS office passed ICDL with excellent scores. ChemBioOffice, ACDlab, MestReNova, SciFinder.
- ACD/Labs Software Workshop for Natural Products Scientists, Tradewinds Island Grand, St Petersburg Beach, Florida, July 10, 2010
2. Flash chromatography, Tradewinds Island Grand, St Petersburg Beach, Florida, July 10, 2010
3. Dereplication workshop, Tradewinds Island Grand, St Petersburg Beach, Florida, July 10, 2010
- Nanoscience and Nanotechnology workshop, faculty of science , Beni Suef University, Egypt, April 9-12, 2012
- The 2nd International Training Course on Plant Tissue Culture Applications, Agriculture Research Center, Cairo, Egypt, May 11-17, 2014
6. NMR workshop, joint meeting between 55th American Society of Pharmacognosy (ASP) & the 14th Annual International Conference on the Science of Botanicals (ICSB) , Oxford Conference Center, Oxford, MS, USA, August 2nd, 2014
7. Recent trends in natural products drug discovery and analysis, Faculty of Pharmacy, Cairo University, December 8-9, 2014.
8. AVANCE 1D/2D: Introduction to AVANCE Spectrometer operation, Fallenden, Swittzerland, March 16-20, 2015
(Faculty & Leadership Development Project; FLDP, Beni Suef University, Beni suef, Egypt):
- Time management and work stress, June 20th – June 22nd (2006).
- Thinking skills development, June 24th – June 26th (2006).
- Effective presentation skills, June 27th – June 29th (2006).
- Effective Teaching, February, 1st- February 5 the (2007)
- Credit Hour System, January 8th - January 10th (2008)
- preparing competitive project for research funding, November 9th - November 11th (2010)
- Strategic Planning, November 23rd - November 25th (2010)
- Actively participated in the Faculty & Leadership Development Project, Nahda University (NUB), Sheraton, Cairo, September 12th -13th (2011)
- Self-Marketing, DAAD Kairo Akademie, 16 May, 2013
10. Financial and legal affairs in university
Master Title
Pharmacognostical study of Hordeum vulgare L. family Graminae growing in Egypt’
Master Abstract
1-All tested extracts showed strong to moderate activities against Staphylococcus aureus and acid fast bacilli .
2- The gramine showed strong activity against Gram-positive bacteroa (Staphylococcus aureus, Bacillus subtilis and Sarcina lutea),Gram - negative bacteria (Eschericia coli) yeast. No activity against acid fast bacilli (Mycobacterium pheli).
3- Only young leaf alcohol extract showed strong antifungal activity perhaps due to the presence of gramine alkaloid.
PHD Title
Comparative phytochemical and biological study of certain plants of family Cycadaceae cultivated in Egypt
PHD Abstract
Cycas is the only currently known genus of the family Cycadaceae, order Cycadales. Chemical investigation of the constituents of Cycas revoluta Thunb. and C. circinalis L. leaflets afforded two new dihydrobiflavone glycosides; I-(2,3)-dihydro-I-7-O-ß-D-glucopyranosylamentoflavone (6) I-(2,3)-dihydro-I-7, II-7-di-O-ß-D-glucopyranosylamentoflavone (7) from C. revoluta and one new biflavonoid, (2S,2?S)-2,3,2?,3?-tetrahydro-4',4?-di-O-methylamentoflavone (tetrahydroisoginkgetin, 10) from C. circinalis in addition to thirty compounds, twenty-one of which are isolated for the first time from the two species. The isolated compounds include fourteen biflavonoids, three lignans, four flavan-3-ols, six flavonoid glycosides, two nor-isoprenoids, and one flavanone. This is the first report of NMR and CD data of 2,3-dihydro-4'-O-methyl- and 2,3,2?,3?-tetrahydro-4'-O-methyl- amentoflavone (4) and (9). The CD spectrum of compound 7 showed a stable atropisomer which is seen for the first time in amentoflavone class. The structure elucidation of these compounds was established via HR-ESIMS, CD, 1D and 2D NMR techniques. The effect of O-methylation on the chemical shifts of the neighboring carbons in the 13C NMR spectra of the dihydro- and tetrahydro-amentoflavone skeletons is discussed. Analytical RP-HPLC study of different plant organs concerning their content of six biflavonoids was done. Results showed the presence of similar biflavonoid picture in the leaflets and the rachis. The seeds showed the presence of hinokiflavone and its dihydroderivative which is different from reported data. The isolated compounds were screened for the cytotoxic, antimicrobial, and antiprotozoal activities. The new compound tetrahydroisoginkgetin (10) showed cytotoxicity to the breast ductal carcinoma with IC50 =12 µg/mL. Hinokiflavone (15) showed cytotoxicity to the melanoma with IC50 =13.4 µg/mL. Isoginkgetin (14) and dihydrobilobetin (4) showed cytoxicity to more than one cell lines with different IC50. Dihydroamentoflavone (3), tetrahydrobilobetin (9) and the new compound tetrahydroisoginkgetin (10) displayed moderate antibacterial activity against Staph. aureus (IC50 values of 8.2, 9.6, and 3.8 µM, respectively) and methicillin-resistant Staph. aureus (MRSA) (IC50 values of 11.5, 12.5, and 5.9 µM, respectively). Vitexin rhamnoside (21) showed antileishmanial activity of IC50 and IC90 of 13.4 and 34.6 µM compared to pentamidine (2.9, 14.7 µM) and amphoericine B (0.1, 0.35 µM).
Keywords: Cycadales, Cycadaceae, Cycas revoluta, Cycas circinalis glycoside, biflavonoid, atropisomer, antimicrobial, cytotoxicity ,antileishmanial.