البيانات الاساسيه
السيره الذاتيه
السيره الذاتيه
رباب محمد عبد السلام عبد اللطيف
القائم باعمال وكيل الكلية لشئون التعليم والطلاب (اكتوبر2015- يوليو 2016)
القائم باعمال رئيس قسم العقاقير (اكتوبر 2014 – يوليو 2015)
استاذ مساعد بقسم العقاقير كلية الصيدله جامعة بني سويف – مصر.... 2012- الان
دكتوراه في العلوم الصيدليه جامعة المسيسيبي - الولايات المتحده ............ 2006
ماجستير العلوم الصيدليه كلية الصيدله جامعة اسيوط – مصر.................1998
بكالوريوس العلوم الصيدليه – تقدير ممتاز مع مرتبة الشرف – المركز الاول1993
الخبره في مجال التدريس:
1- طلبة كلية الصيدله من 1998 حتى الان
2- طلبة الدراسات العليا من 2006 حتى الان
الخبره في البحث العلمي
1- اكتشاف علاجات جديدة من النباتات الارضية و البحرية
2- البحث عن مصادر بيئيه جديده لعلاخات مستحدثه
3- ابحاث في مجال الكيمياء الصيدلية الطبيعية في مجلات عالمية متخصصة
الخبره في العمل الجامعي
1-الحضور والمشاركه الفعاله في مؤتمرات الجامعه العلميه
2- تدريب طلاب الجامعه من كليات مختلفه في دورات الطرق الى التعليم العالي
3- العمل مع طلاب كلية الصيدله في زيارات لدور الايتام والمسنين
4- المشاركه مع طلاب الكلية في قوافل طبيه وتوفير ادويه لدور الايتام والمسنين
عنوان رسالة الماجستير
دراسة عقاقيرية لنبات الابيريا كافرا
ملخص رسالة الماجستير
Alkaloids from the Leaves of Aberia caffra Article in Indian Journal of Chemistry Section B 39(3):215-219 · March 2000 Abstract Two new alkaloids have been isolated from the leaves of Aberia caffra, and characterised as aberiamine N1 pentyl-10-(1,3-dimethylhexahydro-2-pyrimidinyl)-1-dacanamine and aberiamide N-1[{E)-1-butenyl 17-dimethylcarboxamidoheptadecyl)amino}methyl]-N-1-methylacetamide. In addition to α- ,β-amyrin, β-sitosterol and its glucoside, three flavonoids, have also been isolated. Identification of these compounds has been done by spectral analysis and comparison with authentic samples.
عنوان رسالة الدكتوراه
دراسة عقاقيرية لبعض الاسفنجيات البحرية
ملخص رسالة الدكتوراه
ABSTRACT
Marine invertebrates and in particular sponges continue to be a plentiful source of
bioactive secondary metabolites. One especially promising class of compounds continues
to be the modified peptides. Structurally this class includes linear peptides, peptide
lactones, cyclic peptides and depsipeptides. Cyclic peptides are common metabolites from
sponges, and a number of these peptides have been isolated and identified from different
species of the genus Phakellia and Axinella sponges, and were reported to have cytotoxic
activity against a number of cancer cell lines. An investigation of active sponge extracts
yielded two new cyclic heptapeptides, stylisin 1 and 2 and phakellistatin 13 in addition to
the alkaloids, oroidin, stevensine, and sceptrin from the sponge Stylissa caribica.
Phakellistatin 13 was previously isolated from the sponge Phakellia fusa Thiele, and
reported to have potent cytotoxic activity against the human hepatoma BEL-7404 cell line
with an ED50 < 0.01 μg/mL. However, phakellistatin 13 was isolated from Stylissa
caribica sponge, was elucidated independently, and was proven to be non-cytotoxic in the
NCI tumor cell panel and against Vero cells. The new structures were assigned based on
the 1D and 2D NMR spectroscopic data, as well as chemical methods for the elucidation
of the absolute configuration of the amino acids. The new peptides, phakellistatin 13 and
the alkaloids have been evaluated for their antimicrobial, antiprotozoal, antiHIV-1,
antiMtb, antitumor and anti-inflammatory activities, and were not active.
The sponges of the genus Plakortis from the marine environment have been known to
produce a variety of bioactive natural products, especially cyclic peroxide containing
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metabolites. These metabolites have been found to exhibit a diverse range of bioactivities
including anticancer, antibacterial, antifungal and Ca2+ uptake by the cardiac sarcoplasmic
reticulum. The new cyclic peroxide, plakortisinic acid, a new ketone derivative, an α,β-
unsaturated ester, plakortide F and its free acid, plakortone D, plakortide N, and a furan
containing metabolite, were isolated from a Jamaican Plakortis sponge. The structures
were elucidated by interpretation of the 1D, 2D NMR, MS data and by comparison with
data from the literature values. The free acid of plakortide F was shown to have activity
against a number of human diseases such as Leishmania donovani with an IC50 of 2.8
μg/mL, C. albicans with an IC50 of 1.5 μg/mL, and was reported to have cytotoxic activity
against P388 murine leukemia with an IC50 of 0.5 μg/mL. Chemical transformations of
this metabolite have been accomplished in order to optimize the activity and evaluate the
SAR. Thirty-five semisynthetic analogs were prepared, purified and the structure of each
was confirmed with 1H, 13C-NMR and HRMS spectroscopy. The natural products as well
as the synthetic analogs have been assayed against several human diseases. This is the first
report of the α,β-unsaturated ester and plakortone D potently inhibited HIF-1 factor with
95% inhibition at a concentration of 5ppm. Several analogs were more active than the
parent compound as antimalarial, antiMtb and antiHIV-1 agents.
The volatile oil 2-decanone was successfully isolated in high yield from another common
Caribbean Plakortis sponge. It has been determined that 2-decanone is the metabolite
responsible for the fragrant odor and control of biofouling for this sponge. Results from
our biofouling studies using zebra mussels (Dreissena polymorpha) have shown that 2-
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decanone has significant antifouling properties when coated on the surface of an easily
fouled substrate.