Basic Informations

C.V

Curriculum Vitae of Dr/Ahmed M. Gouda Said

 

 

Education: 

• B.Sc. Pharmacy and Pharmaceutical Sciences, Cairo University, Beni-Suef Branch (excellent honor) June 2000.
• M.Sc. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Cairo University, December 2006, entitled: “Synthesis of Some Fused Pyrrolizine Derivatives of Anticipated Biological Activity”.
• Ph.D. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Beni-Suef University, Jul 2009, entitled: “Synthesis of some novel azaheterocyclic derivatives of diverse biological activities

 

Professional Appointments:

• Ø Demonstrator in Pharmaceutical Chemistry Department, Cairo University, Beni-Suef Branch, 2001-2006.
• Ø Assistant Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, 2006-2009.
• Ø Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, 2009- 2011.
• Ø Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, 2009- 2011.
• Ø Assistant prof. of medicinal Chemistry, Collage of Pharmacy, Umm Al-Qura University, 2011- till now.

SCIENTIFIC ACTIVITIES:

A- Teaching & Supervision Activities

 

B.Pharm Courses:

1.  Teaching and supervising the practical courses of pharmaceutical Chemistry for the undergraduate students (B.Pharm. fourth & fifth year) in Faculty of Pharmacy, Beni-Suef University 2001-2006.

2.  Teaching and supervising the practical courses of medicinal Chemistry for the undergraduate students (B.Pharm. medicinal. Chemistry 1,2 & 3) in Faculty of Pharmacy, Nahda University 2009-2011.

3.  Teaching the theoretical course (Medicinal Chemistry -1, 2 & 3) for the undergraduate students (B.Pharm. fourth & fifth year) in Faculty of Pharmacy, Beni-Suef University 2009-2011.

4.  Teaching the theoretical course (B.Pharm. Medicinal Chemistry I, II & III) for the undergraduate students in Faculty of Pharmacy, Nahda University 2009-2011.

5.  Participation in the practical and theoretical Notes of Medicinal Chemistry to the undergraduate students of the fourth and fifth year in Faculty of Pharmacy, Beni-Suef University 2009-2011.

6.  Participation in the practical courses (B.Pharm. medicinal chemistry III & IV) for the undergraduate students in Faculty of Pharmacy, Umm Al-Qura University 2011-2012

7.  Teaching the theoretical courses (B.Pharm. medicinal chemistry III & IV for the undergraduate students in Faculty of Pharmacy, Umm Al-Qura University 2011-2012

Clinical/Pharm.D Courses:

1.  Teaching and supervising the practical courses of medicinal Chemistry for the undergraduate students (clinical pharmacy, 5^th and 6^th level) in Faculty of Pharmacy, Beni-Suef University 2009-2011.

2.  Participation in the practical and theoretical Nnotes of Medicinal Chemistry to the undergraduate students (clinical Pharmacy, 5^th and 6^th level) in Faculty of Pharmacy, Beni-Suef University 2009-2011.

3.  Teaching the theoretical course (Medicinal Chemistry-1 and 2) for the clinical pharmacy undergraduate students (clinical pharmacy, 5^th and 6^th level) in Faculty of Pharmacy, Beni-Suef University 2009-2011.

4.  Participation in the practical and theoretical drug design course for the fourth year students (clinical pharmacy, 7^th level 2010-2011).

5.  Teaching the practical course of Medicinal Chemistry II to the undergraduate students (Pharm.D program,) in Faculty of Pharmacy, Umm Al-Qura University 2011-2012.

6.  Teaching the theoretical course of Medicinal Chemistry I to the undergraduate students (Pharm.D program,) in Faculty of Pharmacy, Umm Al-Qura University 2011-2012.

 

Postgraduate Courses:

 

1.  Teaching and supervising in Medicinal Chemistry for the postgraduate students in Faculty of Pharmacy, Beni-Suef University.

2.  Undergraduate and postgraduate course specification.

E-learning

1.  Creation of the medicinal chemistry course sites, and working with the ELS with high efficacy (black board)

2.  Attendance in E-learning program workshop (desire2learn) in Umm Al-Qura University

 

Supervision & External Examiner

3.  Oral examiner for undergraduate students in faculties of pharmacy (Beni-Suef, Nahda, Cairo & El-Menia Universities).

4.  Supervising the summer training of undergraduate students at Faculty of Pharmacy, Beni-Suef University 2009-2011.

ADMINISTRATION WORK:

1. Participation in the committee for examination of scientific apparatus for the Medicinal Chemistry Department 2009-2011.
2. Participation in the committee for examination of laboratory chemicals and glassware for the Medicinal Chemistry Department.
3. Coordinator in the committee for laboratory chemicals and glassware in pharmaceutical Chemistry Department, faculty of pharmacy, Umm Al-Qura University (2011-2012).
4. Membership in the quality & evaluation committee in pharmaceutical Chemistry Department, faculty of pharmacy, Umm Al-Qura University (2011-2012).
5.  Membership in the curriculum committee in pharmaceutical Chemistry Department, faculty of pharmacy, Umm Al-Qura University (2011-2012).
6. Participation in Performance Appraisal and Quality Assurance Unit, faculty of pharmacy, Beni-Suef University (2002-2003).
7. Coordinator of quality committee, pharmaceutical chemistry department, faculty of pharmacy, Umm Al-Qura University (2011-2012).
8. Coordinator of curriculum committee, pharmaceutical chemistry department, faculty of pharmacy, Umm Al-Qura University (2012-2013).
9. Coordinator of quality committee, B.Pham. program, faculty of pharmacy, Umm Al-Qura University (2012).

Society Services:

1.  Presentation of two lecture on "medication errors" in maternity & children's hospital, Mekka, KSA (2011-2012)

2.  Participation & supervising the "drug formulary index" for maternity & children's hospital, Mekka, KSA (2012)

3.  Presentation of one lecture "drug-drug interaction" in maternity & children's hospital, Mekka, KSA (2011-2012)

ACADEMIC SOCIETY MEMBERSHIP:

Member of the Syndicate of Pharmacists 2000 – till now.

AWARDS:

ý  Beni-Suef University, December 2010. Award for international publication, December 2010.

ý  Nahda University, Award for the best ELS effective course site, March 2011

SUPERVISION OF THESIS:

1. Supervising a Master thesis presented by the pharmacist/ Fadwa Hammad entitled “Synthesis of some pyrrolizine derivatives of anticipated anticancer activity.
2. Supervising a Master thesis presented by the pharmacist/ Ahmed M. Safoate entitled “Synthesis of some pyrrolizine and indolizine derivatives of anticipated biological activity".

TRAINING COURSES:

 

General courses:

ý  Training courses in computer (2009)

ý  English Toefl Test scores 536 (Foreign Language development and teaching center 2008)

ý  University Lecturer Preparative Courses (2009)

ý  Participation in Performance Appraisal and Quality Assurance Unit work shop (2002-2003).

ý  Attendance & pass in development programs for the abilities of university staff & leaders (Beni-Suef University 2009)

ý  Development programs (Nahda University, Cairo, Egypt, 2010)

Training Courses in FLDP (2003-2008).

ý  Active communication skills program

ý  Ethics of university professions.

ý  Exams & student assessment methods

ý  Financial& law sides in university  

ý  Research Time management

ý  Making decisions & problem solving program

ý  Quality assurance & accreditation program

ý  Credit hours program

E-learning courses:

ý  Learning & Content Environment

ý  Electronic Testing & Assessment Tools

ý  Virtual Classroom 'Adobe'

Accreditation & Quality Assurance:

ý  Programs & courses description

ý  Programs & courses description

Reviewer, external evaluator:

1. Review & evaluation of two project proposal for Taif University (2011-2012)
2. Review of two original articles for Beni-Suef University Journal of Applied Sciences (2012)

 

List of Publication

 1.    El-Moghazy, S. M.; Mohamed, M. A. A; Farag, A. E. and Gouda, A. M., “Synthesis and antitumor activity of some 5H-pyrrolizine, pyrimido[5,4-a]pyrrolizine, pyrimido[4,5-b]pyrrolizine derivatives”, S.P.J., 17, 3-18(2009).

 2.    Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim, Ahmed M. Gouda; ‘’Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies’’, Eur. J. Med. Chem. 45 (2010) 482–491

 3.    Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim, Ahmed M. Gouda; Design, Synthesis and Preliminary Evaluation of Some Novel [1,4]Diazepino[5,6-b]pyrrolizine and 6-(2-Oxopyrrolidino-1-yl)-1H-pyrrolizine Derivatives as Anticonvulsant Agents. Med. Chem. Res. 20 (2011) 1015-1023

 4.    Ahmed M. Gouda, Mohamed T. Alsaady, Basem A. Shehata." Design, Synthesis, In Silico Studies and Biological Evaluation of Some Novel Pyrrolizine Derivatives as Safe Antiinflammatory Agents" International Conference on Advanced Basic and Applied Sciences.  Hurghada, Egypt 2012, November 6-9. Poster presentation.

 5.    Mohammed, A.K.A.; Meabed, M.H.; El.-Malah, W.M.; AbdelrahimM.E. and Goda, A.M.Comparison between the Effect of Sildenafil versus Nifedipine in the Treatment of Pulmonary Hypertention in Children, British Journal of Pharmacology and Toxicology 4(2): 51-55, 2013

 6.    Nafady, M.; Attallah, K.; Sayed, M. Aand Gouda A. Formulation and evaluation of a A buoyant Ranitidine hydrochloride system, Int. J. Pharm. Sci. Rev. Res. 24(2), 2004, 4-8

  7.       Gouda, A.M.; Abdelazeem, A.H.; Arafa, E.A.  and Abdellatif, K.R., design, synthesis and pharmacological evaluation of novel pyrrolizine derivatives as potential anticancer, Bioorg. Chem.  53 (2014) 1.

  8.       Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba, Design, synthesis and biological evaluation of novel diphenylthiazole-based cyclooxygenase inhibitors as potential anticancer agents. Bioorg. Chem.  57 (2014) 132–141.

  9.       Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba^; Synthesis and Anticancer Evaluation of Novel Thiazolidinone-Based Cyclooxygenase Inhibitors; The 8th Dubai International Conference for Medical Sciences; 16-17 December,2014 - Al Bustan Rotana Hotel, Dubai, United Arab Emirates

10.   Amany Belal, Ahmed M. Gouda, Ahmed Safwat, Nagwa Abd El-Gwad, Synthesis of novel indolizine, diazepinoindolizine and pyrimido indolizine derivatives as potent and selective anticancer agents, Research on Chemical Intermediates, 41 (12), (2015), pp 9687-9701.

11.   Ahmed M. Gouda, Ahmed H. Abdelazeem, Hany A. Omar^; Design, Synthesis and Biological Evaluation of Novel Pyrrolizine Derivatives as Potential Apoptosis Inducer Anticancer. The 5ht international conference of the division of pharmaceutical and drug industry (advances in pharmaceutical research); 29-30 March 2015, National research center, 33 Al Behous, Ad Doqi, Cairo, Egypt.

12.   Waleed H AlMalki1, Ahmed M Gouda1, 2, Mohamed A Mohamed1, 3 and Hamed I Ali, design, Synthesis and biological evaluation of novel pyrrolizine derivatives as safe anti-inflammatory agents, poster presentation, European Pharma Congress, August 25-27, 2015 Valencia, Spain, DOI: 10.4172/2376-0419.S1.006.

13.   Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-inflammatory/Analgesic Activities and Low Ulcerogenic Liability, Molecules 2016, 21(2), 201; doi:10.3390/molecules21020201.

Master Title

Synthesis of Some Fused Pyrrolizine Derivatives of Anticipated Biological Activity

Master Abstract

ABSTRACT In the present work, seventy one target compounds have been designed and synthesized; they are classified into seven main series. The first comprises derivatives of ethyl-1-cyano-3-phenylcarbamoyl-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. The second comprises derivatives of 2,4-dioxo-1H-pyrimido[4,5-b] pyrrolizine-9-carbonitrile. The third comprises derivatives of 1-cyano-2-(3-substituted ureido)-3N-phenyl-6,7-dihydro-pyrrolizine-3-carboxamide. The fourth comprises derivatives of 3-(substituted)-4-imino-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. The fifth comprises derivatives of 4-amino-3-(substituted)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. The sixth comprises derivatives of 2-amino-3N-phenyl-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide. The seventh comprises derivatives of 4-oxo-9N-phenyl-4,5,6,7-tetrahydro-3H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. Our aim was the design, synthesis and bioscreening of new antineoplastic compounds depending on the structural correlation with several reported antineoplastic pyrrolizines. 2-Amino-1-cyano-3N-phenyl-6,7-dihydro-5H-pyrrolizine-3-carboxamide and substituted carboxamide 73 were reacted with ethyl chloroformate and alkyl / aryl isocyanates to give 2-ethyl carbamoyl derivatives 57 and 2-(3-alkyl /3-aryl)ureido derivatives 59 which upon refluxing in sodium ethoxide afforded the tricyclic pyrimido[4,5-b]pyrrolizines 58 and pyrimido[5,4-a]pyrrolizines 60 respectively. The tricyclic pyrimido[5,4-a]pyrrolizine was obtained by refluxing compound 73 with formic acid. 4-Imino group of compounds 60 were reduced using sodium borohydride to give the 4-amino analogs. Hydrolysis of the 1-cyano group of compounds 73 to 1-carboxamide was carried out using alkaline hydrogen peroxide. In addition 2-amino-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxamide 66 was reacted with acid chloride, phenyl isocyanate and benzaldehyde to give 2-acyl amino 69, 2-(3-aryl ureido) 74 and 2-benzylideneamino 70 derivatives respectively. Hydrolysis of the cyano to carboxamide group was achieved using alkaline hydrogen peroxide. The tricyclic derivatives pyrimido[4,5-b]pyrrolizine 67 and pyrimido[5,4-a]pyrrolizine 68 was obtained by refluxing compound 66 with ethyl chloroformate and formic acid respectively. Eleven new compounds were selected for screening their antitumor activity against breast cell line in National Cancer Institute. The data were treated with a computerized program (probit analysis) in order to calculate the IC50 and IC10 of these compounds. Synthesis of the following compounds was found to be essential for our study. Known intermediate 1- 2-Pyrrolidin-2-ylidene-malononitrile 2- 2-Chloro-1N-phenylacetamide. 3- 2-Chloro-1N-(4-methylphenyl)acetamide. 4- 2-Chloro-1N-(4-methoxyphenyl)acetamide. 5- 2-Chloro-1N-(4-chlorophenyl)acetamide. 6- 2-Chloro-1N-(4-sulfamoylphenyl)acetamide. 7- 2-Amino-1-cyano-3N-phenyl-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 8- 2-Amino-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxylic acid. New compounds that were synthesized 1- Ethyl-1-cyano-3-phenylcarbamoyl-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. 2- Ethyl-1-cyano-3-(4-methylphenylcarbamoyl)-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. 3- Ethyl-1-cyano-3-(4-methoxyphenylcarbamoyl)-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. 4- Ethyl-1-cyano-3-(4-chlorophenylcarbamoyl)-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. 5- Ethyl-1-cyano-3-(sulphamoylphenylcarbamoyl)-6,7-dihydro-5H-pyrrolizin-2-yl-carbamate. 6- 2,4-Dioxo-3-phenyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[4,5-b]pyrrolizine-9-carbonitrile. 7- 2,4-Dioxo-3-(4-tolylphenyl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[4,5-b] pyrrolizine-9-carbonitrile. 8- 3-(4-Methoxyphenyl)-2,4-dioxo-2,3,4,6,7,8-hexahydro-1H-pyrimido[4,5-b] pyrrolizine-9-carbonitrile. 9- 3-(4-Chlorophenyl)-2,4-dioxo-2,3,4,6,7,8-hexahydro-1H-pyrimido[4,5-b] pyrrolizine-9-carbonitrile. 10- 2,4-Dioxo-3-(4-sulfamoylphenyl)-2,3,4,6,7,8-hexahydro-1H-pyrimido[4,5-b] pyrrolizine-9-carbonitrile. 11- 1-Cyano-2-(3-ethylureido)-3N-phenyl-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 12- 1-Cyano-2-(3-ethylureido)-3N-(4-tolyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 13- 1-Cyano-2-(3-ethylureido)-3N-(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 14- 3N-(4-Chlorophenyl)-1-cyano-2-(3-ethylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 15- 1-Cyano-2-(3-ethylureido)-3N-(4-sulfamoylphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 16- 1-Cyano-3N-phenyl-2-(3-phenylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 17- 1-Cyano-3N-(4-methylphenyl)-2-(3-phenylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 18- 1-Cyano-3N-(4-methoxyphenyl)-2-(3-phenylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 19- 1-Cyano-3N-(4-chlorophenyl)-2-(3-phenylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 20- 1-Cyano-2-(3-phenylureido)-3N-(4-sulfamoylphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 21- 1-Cyano-2-[3-(4-chlorophenyl)ureido]-3N-phenyl-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 22- 1-Cyano-2-[3-(4-chlorophenyl)ureido]-3N-(4-methylphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 23- 1-Cyano-2-[3-(4-chlorophenyl)ureido]-3N-(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 24- 1-Cyano-2-[3-(4-chlorophenyl)-ureido]-3N-(4-chlorophenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 25- 1-Cyano-2-[3-(4-chlorophenyl)ureido]-3N-(4-sulfamoylphenyl)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 26- 3-Ethyl-4-imino-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-carboxamide. 27- 3-Ethyl-4-imino-2-oxo-9N-(4-methylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-carboxamide. 28- 3-Ethyl-4-imino-2-oxo-9N-(4-methoxyphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-carboxamide. 29- 9N-(4-Chlorophenyl)-3-ethyl-4-imino-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-carboxamide. 30- 3-Ethyl-4-imino-2-oxo-9N-(4-sulfamoylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-carboxamide. 31- 4-Imino-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-(N-phenylcarboxamide). 32- 4-Imino-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-(N-(4-methylphenyl)carboxamide). 33- 4-Imino-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-(N-(4- methoxyphenyl)carboxamide). 34- 4-Imino-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-(N-(4-chlorophenyl)carboxamide). 35- 4-Imino-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a] pyrrolizine-9-(N-(4-sulfamoylphenyl)carboxamide). 36- 3-(4-Chlorophenyl)-4-Imino-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-(N-phenylcarboxamide). 37- 3-(4-Chlorophenyl)-4-imino-9N-(4-methylphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 38- 3-(4-Chlorophenyl)-4-imino-9N-(4-methoxyphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 39- 3-(4-Chlorophenyl)-4-imino-2-oxo-9N-(4-chlorophenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 40- 3-(4-Chlorophenyl)-4-imino-2-oxo-9N-(4-sulfamoylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 41- 4-Amino-3-ethyl-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 42- 4-Amino-3-ethyl-9N-(4-methylphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 43- 4-Amino-3-ethyl-9N-(4-methoxyphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 44- 4-Amino-9N-(4-chlorophenyl)-3-ethyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 45- 4-Amino-3-ethyl-2-oxo-9N-(4-sulfamoylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 46- 4-Amino-2-oxo-3-phenyl-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 47- 4-Amino-9N-(4-methylphenyl)-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 48- 4-Amino-9N-(4-methoxyphenyl)-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 49- 4-Amino-9N-(4-chlorophenyl)-2-oxo-3-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 50- 4-Amino-2-oxo-3-phenyl-9N-(4-sulfamoylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 51- 4-Amino-3-(4-chlorophenyl)-2-oxo-9N-phenyl-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 52- 4-Amino-3-(4-chlorophenyl)- 9N-(4-methylphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 53- 4-Amino-3-(4-chlorophenyl)- 9N-(4-methoxyphenyl)-2-oxo-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 54- 4-Amino-2-oxo-3-(4-chlorophenyl)-9N-(4-chlorophenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 55- 4-Amino-2-oxo-3-(4-chlorophenyl)-9N-(4-sulfamoylphenyl)-2,3,4,5,6,7-hexahydro-1H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 56- 2-Amino-3N-phenyl-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide. 57- 2-Amino-3N-(4-methylphenyl)-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide. 58- 2-Amino-3N-(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide. 59- 2-Amino-3N-(4-chlorophenyl)-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide. 60- 4-Oxo-9N-phenyl-4,5,6,7-tetrahydro-3H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 61- 3N-(4-Methylphenyl)-4-oxo-4,5,6,7-tetrahydro-3H-pyrimido[4,5-a]pyrrolizine-9- carboxamide. 62- 3N-(4-Methoxyphenyl)-4-oxo-3H-4,5,6,7-tetrahydro-pyrimido[4,5-a]pyrrolizine-9- carboxamide. 63- 2-Amino-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 64- 2-Acetamido-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 65- 2-Benzoylamido-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 66- 9-Cyano-2,3,4,5,6,8-hexahydro-1H-pyrimido[4,5-b]pyrrolizine-2,4-dione. 67- 1-Cyano-2(3-phenylureido)-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 68- 1-Cyano-2(3-(4-chlorophenyl)ureido)-6,7-dihydro-5-pyrrolizine-3-carboxamide. 69- 2-(Benzylideneamino)-1-cyano-6,7-dihydro-5H-pyrrolizine-3-carboxamide. 70- 4-Oxo-4,5,6,7-tetrahydro-3H-pyrimido[5,4-a]pyrrolizine-9-carboxamide. 71- 2-Amino-6,7-dihydro-5H-pyrrolizine-1,3-dicarboxamide.

PHD Title

Synthesis of some novel azaheterocyclic derivatives of diverse biological activities

PHD Abstract