Basic Informations

C.V

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Master Title

Phytochemical and biological studies of Ficus platypoda (Miq.) A. Cunn. and Ficus lyrata Warb., family Moraceae, cultivated in Egypt

Master Abstract

• The two species of Ficus platypoda (Miq.) A. Cunn and Ficus lyrata Warb. were subjected to RAPD assay of the genomic DNA; this was performed using eleven different primers. The number of RAPD-PCR fragments indicates that the eleven primers were reproduced. The low percentage of similarity coefficients indicates that the two species are not closely related . • Proximate analysis, TLC profiling and quantitative analysis of the phenolic contents of the leaves of both species showed variation in their composition which could be used for their differentiation. • Ten compounds have been isolated from the leaves of both species. Their structures were elucidated via physico-chemical characterization and spectroscopic analysis. These include; one phenolic acid (isolated for the first time from nature), three flavonol glycosides, one flavonol aglycone, two triterpenoids, two sterols and one sterol glucosides. • The 80 % ethanol extracts of the leaves of both species could be considered as safe based on acute toxicity study. • Biological screening revealed that the 80 % ethanol extract of the leaves of Ficus platypoda (Miq.) A. Cunn. and Ficus lyrata Warb. showed pronounced antihyperglycemic and a moderate antioxidant activities which recommends its incorporation in suitable dosage forms after further biological studies. • The previous findings recommend the intensive propagation of these indigenous plants especially Ficus platypoda (Miq.) A. Cunn. for probable implementation in the pharmaceutical industry. • However, this achievement will not be possible unless the different extractives and/or pure isolates are subjected to thorough laboratory biological investigation, and sub-clinical and clinical studies.

PHD Title

Phytochemical and Biological Studies of Different Plants Belonging to Salicaceae and Arecaceae Family, Cultivated in Egypt

PHD Abstract

Phytochemical study of Flacourtia rukam leaves and bark led to the isolation and identification of eighteen phenolic compounds (five of them were new), one triterpene, two sterols and one diterpene. Compound F11 (Biphenyl-1,1',2,2'-tetrol) exhibited a good antitrypanosomal activity and considered as a drug lead. All organs of Flacourtia rukam cultivated in Egypt need more chemical and biological investigations. Semi-synthesis of new derivatives for compounds isolated from Flacourtia rukam is recommended to be carried out. Phytochemical study of Archontophoenix alexandrae led to the isolation and characterization of seven compounds; stigmasterol and ß-sitosterol mixture, ß-sitosterol-ß-D-glucoside, tricin, quercetin, luteolin, rutin and entepicatechin-(2a?7, 4a?8)-catechin. Phytochemical investigation of Dictyosperma album led to the isolation and characterization of five compounds; stigmasterol and ß-sitosterol mixture, ß-sitosterol-ß-D-glucoside, tricin, rutin and orientin. Flacourtia rukam, Archontophoenix alexandrae (Wendl. & Drude) and Dictyosperma album (Bory) H.Wendl and Dictyosperma album (Bory) H.Wendl & drude ex. Scheff are rich in phenolic constituents. It is recommended that the tested plants need more studies about their antioxidant activity.