Basic Informations

C.V

Curriculum Vitae of Dr. / Noha Hani Amin Metri Personal Data Name: Noha Hani Amin Metri Nationality: Egyptian. Telephone: 00201223471766 E-mail: noha.metri@pharm.bsu.edu.eg or hani.noha@gmail.com  Current Mailing Address: Medicinal Chemistry Department, Faculty of Pharmacy Beni-Suef University. Current Appointment: Lecturer of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, present.

Education

? B. Sc. Pharmacy and Pharmaceutical Sciences, Cairo University (excellent honor) June 1998.

? M. Sc. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Cairo University, 2007, entitled: “Design and synthesis of some acridine derivatives of anticipated neoplasm inhibitor activity”.

? Ph. D. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Beni-Suef University, 2010, entitled: “Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents”

Professional Appointments

? Demonstrator in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Beni-Suef University 1999-2007.

? Assistant Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, 2007-2010.

? Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef, 2010- present.

Training Courses

Training Courses in FLDP.

Teaching Activities

1. Teaching and supervising the practical courses of Medicinal Chemistry for the undergraduate students (fourth & fifth year), Faculty of Pharmacy, Beni-Suef University.

2. Teaching and supervising the practical courses of Analytical Chemistry for the undergraduate students (fourth & fifth year), Faculty of Pharmacy, German University in Cairo.

3. Teaching and supervising the practical courses of Pharmaceutical Chemistry for the undergraduate students (fourth & fifth year), Faculty of Pharmacy, German University in Cairo.

4. Participation in the practical and theoretical books for the fourth year students, Faculty of Pharmacy, Beni-Suef University.

5. Participation in the practical and theoretical books for the fifth year students, Faculty of Pharmacy, Beni-Suef University.

6. Oral examiner for undergraduate students in faculties of pharmacy (Beni-Suef and Cairo).

7. Teaching and supervising in Medicinal Chemistry for the postgraduate students in Faculty of Pharmacy, Beni-Suef University.

List of Publication

1. Synthesis And Anticancer Screening Of Novel Spiro [Chroman-2,4'-Piperidin]-4-One Derivatives With Apoptosis-Inducing Activity. Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Noha H. Amin, Ahmed H. Abdelazeem, Ashraf N. Abdalla, Khaled R.A. Abdellatif. Journal of Applied Pharmaceutical Science. In press. Accepted November 20 (2017).

1. Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors. Khaled Abdellatif, Mohammed T. Elsaadi, Noha H. Amin, A.A. Hefny. Journal of Applied Pharmaceutical Science, 7 (08), 069-077 (2017).

1. Synthesis of some benzoxazole derivatives and their anti-inflammatory evaluation Khaled R. A. Abdellatif, Noha H. Amin and Asmaa A. Mohammed. J. Chem. Pharm. Res., 8 (4), 1253-61 (2016).

4.      Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines". Nagwa M. Abdel Gawad , Noha H. Amin , Mohammed T. Elsaadi , Fatma M. M. Mohamed , Andrea Angeli , Viviana De Luca , Clemente Capasso , Claudiu T. Supuran. Bio. Med. chem, 24, 3043-305, (2016).

1. Synthesis of Novel Pyrazole and Dihydropyrazoles Derivatives as Potential Anti- inflammatory and Analgesic Agents. Nagwa M. Abd-El Gawad, Hanan H. Georgey, Nashwa A. Ibrahim, Noha H. Amin, Rania M. Abdelsalam. Arch. Pharm. Res.  35(5), 807-821 (2012).

1. Synthesis and Antineoplastic activity of certain triazene and triazeno-acridine combilexin derivatives. Samir.M. E. Aly, Hanan H. Georgey, Mohammed A. Mohammed, Nagwa M. Abdel Gawad, Noha H. Amin. Bull. Pharm. Sci., Assiut University, 30(2), 89-110 (2007).

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Master Title

Synthesis and Antineoplastic activity of certain triazene and triazeno-acridine combilexin derivatives

Master Abstract

Abstract Four series of bifunctional ligands have been synthesized as DNA-binding combilexins. These novel agents contain a triazeno-benzene sulfonamide linker moiety that is attached to an intercalating acridine or acridone chromophore by a functionalized amide or ester residue. In order to obtain these combilexins three series of the anticipated antitumor triazeno-benzene sulfonamide were synthesized. The synthesis and bioscreening of the new antineoplastic compounds are depending on the structural correlation with several reported antineoplastic acridines. 2-Chlorobenzoic acid was reacted with anthranilic acid to give N-(2-carboxyphenyl) anthranilic acid which upon cyclodehydration with sulfuric acid afforded 9-oxo-9. 10-dihydrocicridine-4-carboxylic acid, (acridone-4-carboxylic acid) 8. This latter intermediate has been converted to 9-chloroacridine carbonyl chloride 9 using thionyl chloride. Selective substitution of 9 with derivatives of 4-(piperazine-1-yldiazenyl) benzenesulfonamides 4a-e or derivatives of 4-(2-hydroxyethyl)piperazine-1-yl)diazenyl) benzenesulfomaides 5a-e to yield their 9-chloroacridine-4-carboxamides 10a-e and 9-chloroacridine-4-carboxlic acid esters 13a-e respectively. Those intermediates have been reacted either with different sulfonamides to give derivatives of 4-{4-[4-(4 sulfamoylphenyldiazenyl)piperazine-1-carbonyl]-9-ylamino}benzenesulfonamides 11a-h and derivatives of 2-[(4-(4-sulfamoyl-phenyl)diazenyl)perazine-1-yl]ethyl 9-(4-sulfamoylphenylamino)-9,10-dihydroacridine-4-carboxylates 14a-i respectively or subjected to mild acid hydrolysis to yield derivatives of 4-{4-[(9-oxo-9,10-dihydroacridine-4-carbonyl)piperazine-1-yl]diazenyl}-benzenesulfonamide 12a-e and derivatives of 2-{4-[(4-sulfamoyl-phenyl)diazenyl]piperazine-1-yl}ethyl-9-oxo-9,10-dihydroacridine-4-carboxylate 15a-e respectively. Besides, the synthesis of derivatives of 4-(piperazine-1-yldiazenyl) benzenesulfonamides 4a-e and derivatives of 4-(2-hydroxyethyl)piperazine-1-yl)diazenyl) benzenesulfonamides 5a-e has been achieved via diazotization Of various substituted benzene sulfonamides with sodium nitrite and hydrochloric acid followed by various amines coupling to yield the target triazeno-benzene sulfonamides. Fourteen new compounds were selected for screening their antitumor activity against breast cell line in National Cancer Institute. Six of them were found to be active as antitumor agents, while two were found to be mild active.

PHD Title

Synthesis and Pharmacological Activity of Certain Pyrazole Derivatives as Cycloxygenase Inhibitors

PHD Abstract

This study involves a survey covering the synthesis and pharmacological significance of some pyrazole derivatives. The presence of two forms of cycloxygenase enzyme (Cox1 and Cox2) stimulated investigatons to develop more efficient non steroidal anti- inflammatory drugs with reduced side effects compared to the standard NSAIDS through the selective inhibition of one isoform of these enzymes. A number of new pyrazole derivatives were designed, synthesized, and biologically evaluated as anti-inflammatory agents. The most active candidates as anti-inflammatory agents were accordingly tested for their analgesic and ulcreogenic activities. Furthermore, the promising candidates were exposed to molecular modeling simulation using was a docking study on both isozymes of Cyclooxygenase enzyme using the Molegro Virtual Docker software. The results of the in vivo study and virtual screening were coinciding to a great extent.