Basic Informations

C.V

2009 – present              Assistant professor at the Department of Pharmacology and Toxicology,

                                 Faculty of Pharmacy, Beni-Suef University, Egypt.                    

Master Title

Comparative evaluation of the effectiveness of certain gastropathy-preventing drugs against experimentally-induced hyperacidity in animals

Master Abstract

In the present study the possible gastric protective effects of some natural products namely cumin and chamomile oils compared to famotidine. used as 8 reference standard antiulcer agent against piroxicam-induced gastric ulcer have been investigated. Gastric ulceration was induced by either single dose or 14 daily administrations of piroxicam. Piroxicam (5 mg/kg, i.p.) was administered immediately y after pyloric ligation to 48 h. fasted rats. Test drugs namely famotidine (20 mg/kg), cumin oil (400 mg/kg) and chamomile oil (250 mg/kg) were orally administered l h. before pyloric ligation. The ulcerogenic effect of piroxicam and the antiulcerogenic potential s of test drugs were evaluated based on number of ulcers, ulcer index, gastric volume, titratable acidity, acid output, peptic activity and mucin concentration in the gastric juice. The gastric mucosa\ content of histamine, lipid peroxides and glutathione were also evaluated.

PHD Title

Molecular Mechanisms of Modulatory effects of Naturally Occurring Compounds on the Efficacy of Cancer Therapy

PHD Abstract

Combination of innocuous dietary components with anticancer drugs is an emerging new strategy for cancer chemotherapy to increase anti-tumor response and reduce toxicity. Tangeretin, a copiously concentrated flavonoid in the peel of citrus fruits, is an effective natural agent which inhibits cancer cell proliferation. Here, we show an enhanced response of cisplatin-sensitive ovarian cancer cells, cisplatin-resistant ovarian cancer cells, hepatocellular carcinoma and colon cancer cells to various combination treatments of cisplatin and tangeretin. Pretreatment of A2780/CP70 cells with tangeretin prior to cisplatin treatment synergistically inhibited cancer cell proliferation. This combination was effective in activating apoptosis via caspase cascade as well as arresting cell cycle at G2/M phase. Moreover, phospho-Akt and its downstream substrates, e.g., NF-?B, phospho-GSK-3ß and phospho-BAD were down-regulated upon tangeretin-cisplatin treatment. The tangeretin-cisplatin induced apoptosis was increased by phosphoinositide-3 kinase (PI3K) inhibition and siRNA-mediated Akt silencing, but reduced by over-expression of constitutively activated-Akt and GSK-3ß inhibition. The overall results indicated that tangeretin exposure preconditions cisplatin-resistant human ovarian cancer cells for a conventional response to low-dose cisplatin-induced cell death occurring through down-regulation of PI3K/Akt signaling pathway. Thus, tangeretin in combination with chemotherapeutic agents can be applied as a promising modality to overcome the drug resistance in clinical cancer chemotherapy.