Basic Informations
C.V
C.V
Rasha Mohammed Mostafa Kharshoum
NAME: Rasha Mohammed Mostafa Kharshoum
DATE OF BIRTH : 9 / 3 / 1976.
NATIONALITY: Egyptian
STATUS: Married
ADDRESSE : Egypt – Cairo
– Maadi – 1/c Laselkee st.
P.O. BOX: 597 El-Maadi
E-MAIL : rasha0mohd@hotmail.com
PHONE NOMBER: 00201141968805
- 0020225177563
EDUCATION :
1-BS.C of Pharmacy & Pharmaceutical Sciences - Faculty of
Pharmacy -Cairo University in 1998.
Grade : Excellent with Honors
2-Master in Pharmaceutics and Industrial pharmacy in "formulation
of Norfloxacin in different Pharmaceutical Preparations" Faculty of
Pharmacy- Cairo University in (2009).
This thesis included the formulation of Norfloxacin in the form of
dispersible tablets prepared by different techniques such as; freeze drying,
direct compression, etc.
3-PH. D. in Pharmaceutics and Industrial pharmacy in "Pharmaceutical
Study on Ketotifen Fumarate" Faculty of Pharmacy- Beni Suef University (Branch of Cairo University Previously) in (2011).
This thesis included the clinical application of the prepared
sublingual tablets by complex formation with 2HP-β Cyclodextrin and formation of eye drops with
different techniques
LANGUAGE SKILLS:
·
Arabic
·
English -( Excellent )
pass TOEFL ITP.
COMPUTER SKILLS : International
computer driving license {ICDL} , SPSS, photoshop
CURRENT JOB: Assistant professor in
Pharmaceutics and Industrial Pharmacy Department in Beni Suef University
WORK EXPERIENCE:
July 98 to October 99: National
Cancer Institute-
Cairo University
Worked as pharmacist in the field of
clinical and hospital pharmacy
January1999 to July 2011: Faculty of Pharmacy- Beni
Suef University,
Lecturer in Pharmaceutics and
Industrial Position Held
2015-2016 Vice-dean of
social services and environmental affairs. Faculty of Pharmacy, The University
of Beni- Suef, Egypt.
2012-2014 Vice
dean for higher eduation and research, THE University of Beni-Suef, Egypt.
2011-2012 Vice-dean of
social services and environmental affairs. Faculty of Pharmacy, The University
of Beni- Suef, Egypt.
2011-2014 Head of
pharmaceutics and industrial pharmacy department, Faculty of pharmacy. The
University of Beni- Suef, Egypt.
2011-2012 Associate
professor of pharmaceutical nanotechnology, The University of Beni- Suef, Egypt.
2005-2010 Assistant
professors of pharmaceutics and industrial pharmacy
Pharmacy
July
2011 up to date: Faculty of Pharmacy-
Beni Suef University, Assistant
Professor in Pharmaceutics and
Industrial Pharmacy
BUBLICATIONS:
1- Pharmaceutical Development and Technology, 2014. Statistical
optimization of controlled release microspheres containing cetirizine
hydrochloride as a model for water soluble drugs
2- World Journal of Pharmaceutical
Science, 2014; 2(8): 695-703. Modeling of ketoprofen release from a
mucoadhesive orodental gel for better control of dental pain and gingivitis
3-International Journal of drug delivery, 2013; 5 (2): 167-176. Comparative
pharmacokinetic study of two lyophilized orally disintegrating tablets
formulations of vinpocetine in human volunteers
4-International Journal
of Pharmaceutical Sciences, 2014: Preparation and Evaluation of Risperidone
Oro-dispersible Tablets”
5- International Journal
of drug delivery, Volume 4 (2012) 484-491: Development of Sublingual tablets of
Bisoprolol Hemifumarate / Hydroxypropyl –β-Cyclodextrin Complex for Potential
treatment of Angina Pectoris.
6- Al Azhaar Jounal of pharmaceutical science in 2009, volume
40-p:226:240 " Fast dispersible Norfloxacin tablets: formulation,
stability and Bioavailability" ISSN 1110-1644.
7- In the international Egyptian pharmaceutical society XXXII
conference of pharmaceutical sciences: Formulation and Evaluation of Ketotifen
Fumarate Fast Disintegrating Sublingual Tablets
8- International Journal of drug delivery, Volume3 (2011) 228-240:
2-Hydroxypropyl-ß-Cyclodextrin Complex with Ketotifen Fumerate for Eye Drops
Preparations
9. International Journal of drug delivery, Volume 4 (2011) 619-632: Formulation
and Evaluation of Ketotifen Fumarate Fast Disintegrating Sublingual Tablets.
10. Heba A. A, Rasha
M.K, Hatem R.I, Formulation and optimization of solid self nanoemulsifying
system using porous carriers for oral delivery of Cinnarizine International
Journal of Pharmacy and Pharmaceutical Sciences.Vol 8, Issue 1,
2016;
11. Heba A. A, Rasha M.K Formulation, Development
and Evaluation of Meclozine Hydrochloride Microspheres J Bioequiv Availab 2016,
8:1
J Bioequiv Availab 2016, 8:1
All documents are available on request
Master Title
formulation of Norfloxacin in different Pharmaceutical Preparations
Master Abstract
This research paper addressed the formulation and performance of a mucoadhesive gel containing the anti-inflammatory drug ketoprofen. Various polymers were used in the formulation at different levels together with different types of crosslinking additives. The compatibility between ketoprofen and the employed polymers was tested using differential scanning calorimetry (DSC). Sustained release profiles were obtained from gels containing pluroic F127, carbopol981 and polycarbophil. Fast release was obtained from sodium alginate and HPMC at low levels. Response surface modeling of the release data indicated that the optimum ketoprofen release rates (44-58 %) were obtained from gel formulations containing carbopol 981 at 1% w/w level. Gel formulations containing sodium alginate (5 % w/w) released more than 40 % of their content of ketoprofen within two hours. The fastest rate was obtained from formulations containing hydroxylpropyl methylcellulose (HPMC E15) where, more than 90 % of the drug content was released at polymer level of 20 % w/w as obtained from model optimized formulations. The clinical evaluation of the anti-inflammatory and analgesic action of the prepared formulations compared to commercial ketoprofen tablets indicated significant difference (P < 0.05) in pain intensity and swelling associated with ginigivitis in favor of the gel formulation over the oral tablet. Therefore, formulation of ketoprofen into a mucoadhesive orodental gel can be considered an easy and more effective alternative to oral solid dosage forms.
PHD Title
Modeling of ketoprofen release from a mucoadhesive orodental gel for better control of dental pain and gingivitis
PHD Abstract
This research paper addressed the formulation and performance of a mucoadhesive gel containing the anti-inflammatory drug ketoprofen. Various polymers were used in the formulation at different levels together with different types of crosslinking additives. The compatibility between ketoprofen and the employed polymers was tested using differential scanning calorimetry (DSC). Sustained release profiles were obtained from gels containing pluroic F127, carbopol981 and polycarbophil. Fast release was obtained from sodium alginate and HPMC at low levels. Response surface modeling of the release data indicated that the optimum ketoprofen release rates (44-58 %) were obtained from gel formulations containing carbopol 981 at 1% w/w level. Gel formulations containing sodium alginate (5 % w/w) released more than 40 % of their content of ketoprofen within two hours. The fastest rate was obtained from formulations containing hydroxylpropyl methylcellulose (HPMC E15) where, more than 90 % of the drug content was released at polymer level of 20 % w/w as obtained from model optimized formulations. The clinical evaluation of the anti-inflammatory and analgesic action of the prepared formulations compared to commercial ketoprofen tablets indicated significant difference (P < 0.05) in pain intensity and swelling associated with ginigivitis in favor of the gel formulation over the oral tablet. Therefore, formulation of ketoprofen into a mucoadhesive orodental gel can be considered an easy and more effective alternative to oral solid dosage forms.