البيانات الاساسيه

السيره الذاتيه

السيره الذاتيه

رباب محمد عبد السلام عبد اللطيف

القائم باعمال وكيل الكلية لشئون التعليم والطلاب (اكتوبر2015- يوليو 2016)

القائم باعمال رئيس قسم العقاقير (اكتوبر 2014 – يوليو 2015)

استاذ مساعد بقسم العقاقير كلية الصيدله جامعة بني سويف – مصر.... 2012- الان

دكتوراه في العلوم الصيدليه  جامعة المسيسيبي - الولايات المتحده ............ 2006

ماجستير العلوم الصيدليه كلية الصيدله  جامعة اسيوط – مصر.................1998

بكالوريوس العلوم الصيدليه – تقدير ممتاز مع مرتبة الشرف – المركز الاول1993

الخبره في مجال التدريس:

1-   طلبة كلية الصيدله من 1998 حتى الان

2-   طلبة الدراسات العليا من 2006 حتى الان

الخبره في البحث العلمي

1-   اكتشاف علاجات جديدة من النباتات الارضية و البحرية

2-   البحث عن مصادر  بيئيه جديده لعلاخات مستحدثه

3-   ابحاث في مجال الكيمياء الصيدلية الطبيعية في مجلات عالمية متخصصة

الخبره في العمل الجامعي

1-الحضور والمشاركه الفعاله في مؤتمرات الجامعه العلميه

2- تدريب طلاب الجامعه من كليات مختلفه في دورات الطرق الى التعليم العالي

3-  العمل مع طلاب كلية الصيدله في زيارات لدور الايتام والمسنين

4- المشاركه مع طلاب الكلية في قوافل طبيه وتوفير ادويه لدور الايتام والمسنين

عنوان رسالة الماجستير

دراسة عقاقيرية لنبات الابيريا كافرا

ملخص رسالة الماجستير

Alkaloids from the Leaves of Aberia caffra Article in Indian Journal of Chemistry Section B 39(3):215-219 · March 2000 Abstract Two new alkaloids have been isolated from the leaves of Aberia caffra, and characterised as aberiamine N1 pentyl-10-(1,3-dimethylhexahydro-2-pyrimidinyl)-1-dacanamine and aberiamide N-1[{E)-1-butenyl 17-dimethylcarboxamidoheptadecyl)amino}methyl]-N-1-methylacetamide. In addition to α- ,β-amyrin, β-sitosterol and its glucoside, three flavonoids, have also been isolated. Identification of these compounds has been done by spectral analysis and comparison with authentic samples.

عنوان رسالة الدكتوراه

دراسة عقاقيرية لبعض الاسفنجيات البحرية

ملخص رسالة الدكتوراه

ABSTRACT Marine invertebrates and in particular sponges continue to be a plentiful source of bioactive secondary metabolites. One especially promising class of compounds continues to be the modified peptides. Structurally this class includes linear peptides, peptide lactones, cyclic peptides and depsipeptides. Cyclic peptides are common metabolites from sponges, and a number of these peptides have been isolated and identified from different species of the genus Phakellia and Axinella sponges, and were reported to have cytotoxic activity against a number of cancer cell lines. An investigation of active sponge extracts yielded two new cyclic heptapeptides, stylisin 1 and 2 and phakellistatin 13 in addition to the alkaloids, oroidin, stevensine, and sceptrin from the sponge Stylissa caribica. Phakellistatin 13 was previously isolated from the sponge Phakellia fusa Thiele, and reported to have potent cytotoxic activity against the human hepatoma BEL-7404 cell line with an ED50 < 0.01 μg/mL. However, phakellistatin 13 was isolated from Stylissa caribica sponge, was elucidated independently, and was proven to be non-cytotoxic in the NCI tumor cell panel and against Vero cells. The new structures were assigned based on the 1D and 2D NMR spectroscopic data, as well as chemical methods for the elucidation of the absolute configuration of the amino acids. The new peptides, phakellistatin 13 and the alkaloids have been evaluated for their antimicrobial, antiprotozoal, antiHIV-1, antiMtb, antitumor and anti-inflammatory activities, and were not active. The sponges of the genus Plakortis from the marine environment have been known to produce a variety of bioactive natural products, especially cyclic peroxide containing vii metabolites. These metabolites have been found to exhibit a diverse range of bioactivities including anticancer, antibacterial, antifungal and Ca2+ uptake by the cardiac sarcoplasmic reticulum. The new cyclic peroxide, plakortisinic acid, a new ketone derivative, an α,β- unsaturated ester, plakortide F and its free acid, plakortone D, plakortide N, and a furan containing metabolite, were isolated from a Jamaican Plakortis sponge. The structures were elucidated by interpretation of the 1D, 2D NMR, MS data and by comparison with data from the literature values. The free acid of plakortide F was shown to have activity against a number of human diseases such as Leishmania donovani with an IC50 of 2.8 μg/mL, C. albicans with an IC50 of 1.5 μg/mL, and was reported to have cytotoxic activity against P388 murine leukemia with an IC50 of 0.5 μg/mL. Chemical transformations of this metabolite have been accomplished in order to optimize the activity and evaluate the SAR. Thirty-five semisynthetic analogs were prepared, purified and the structure of each was confirmed with 1H, 13C-NMR and HRMS spectroscopy. The natural products as well as the synthetic analogs have been assayed against several human diseases. This is the first report of the α,β-unsaturated ester and plakortone D potently inhibited HIF-1 factor with 95% inhibition at a concentration of 5ppm. Several analogs were more active than the parent compound as antimalarial, antiMtb and antiHIV-1 agents. The volatile oil 2-decanone was successfully isolated in high yield from another common Caribbean Plakortis sponge. It has been determined that 2-decanone is the metabolite responsible for the fragrant odor and control of biofouling for this sponge. Results from our biofouling studies using zebra mussels (Dreissena polymorpha) have shown that 2- viii decanone has significant antifouling properties when coated on the surface of an easily fouled substrate.