Basic Informations

C.V

Name : Waleed Abd Elsalam Ibrahim Mahmoud 
Job : Demonstrator of pharmacology and toxicology 

Master Title

Role of angiotensin receptor blockade in experimentally induced Alzheimer's disease

Master Abstract

? Deposition of A ß 1-42 in brain cortex, hippocampus and cerebellum was significantly decreased when compared with LPS group, Tempol treated group even with the other dose of telmisartan. ? Significant increase in BDNF as neuroplasticity biomarker when compared with LPS group and the other dose of telmisartan. ? Inflammatory biomarker including: TNF a was significantly decreased when compared with LPS group and tempol treated group, iNOS was significantly decreased when compared with LPS group and the other dose of Telmisartan treated group , nNOS and NOx were significantly decreased when it was compared LPS group , tempol treated group and even with the other dose of telmisartan. ? Oxidative stress parameters as MDA and NT were significantly decreased when compared with LPS group, tempol treated group and the other dose of telmisartan treated group while SOD and GSH were significantly increased when compared with LPS group, tempol treated group and the other dose of telmisartan treated group. Depending on the results of the current study, it can be concluded that tempol and the two doses of telmisartan enhance spatial and non spatial memory, reduced Aß 1-42, and increased BDNF also they decreased inflammatory biomarkers as TNF-a, iNOS, nNOS and NOx ,They also decrease MDA, NT while they increased GSH and SOD as an oxidative stress biomarkers when compared with LPS received group.

PHD Title

PHD Abstract