Basic Informations
C.V
Personal Data:
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Name:Mostafa
Mohsen Mostafa Afify
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Date of Birth:
12/1/1978
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Place of Birth:
EL-Minia
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Country of Nationality:
Egypt
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Religion: Muslim
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Marital Status: Married; (2) sons
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Military status: finished.
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Address:
12/27 k, Diar Eltamer compound,
6th of October City, Giza, Egypt
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Telephone: Egypt (002) (02) 37783653
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Mobile : Egypt (002) 01273206767; (002) 01017855559.
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E-mail: doafify@yahoo.com
Qualifications:
09/95-12/01 M.B.B.Ch. in Medicine and Surgery, Faculty of Medicine,
Cairo University, Kasr
El-Ainy Medical School , Egypt.
Grade
Very Good .
10/03-12/05 Master
Degree in Forensic Medicine and Clinical Toxicology, Faculty of Medicine,
Cairo University, Egypt.
Grade Excellent
"Medico legal View of Malpractice Crisis in Obstetrics and
Gynecology"
3/06-1/09 M.D.
in Forensic Medicine and Clinical Toxicology, Faculty of Medicine,
Cairo University, Egypt.
"Age
Dependent Immunomodulation, Genotoxicity and Oxidative Stress due to Pesticide
Mixture Exposure and Protective Potential of Antioxidants in Albino Rats"
Previous Posts:
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2/2001- 2/2002: House officer,
Cairo University Hospitals.
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8/2003- 4/2006:
Demonstrater, Forensic
Medicine and Clinical Toxicology, Beni Suef Faculty of Medicine, Cairo University.
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4/2006- 3/2009: Assistant Lecturer,
Forensic Medicine and Clinical Toxicology,
Beni Suef Faculty of Medicine, Cairo University.
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3/2009- 8/2014: Lecturer, Forensic Medicine and Clinical Toxicology,
Beni Suef Faculty of Medicine, Cairo University.
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8/2014- till
now: Associate professor, Forensic Medicine and Clinical Toxicology,
Beni Suef Faculty of Medicine, Beni Suef University.
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2/2011-
12/2014: Clinical Toxicology Consultant,
Dammam Regional
Poison Control Center, KSA.
Practical and Scientific
Activities:
A. Teaching
& practical Activities in forensic medicine and clinical toxicology department, Faculty of Medicine:
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Teaching and
examining courses of Forensic Medicine for undergraduate students, Beni Suef Faculty of Medicine, Beni Suef
University.
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Teaching and
examining courses of Clinical Toxicology for undergraduate students, Beni Suef Faculty of Medicine, Beni Suef
University
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Teaching and
examining courses of Forensic
Medicine and Clinical
Toxicology for
postgraduate students, Beni Suef Faculty of Medicine, Beni Suef
University.
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Teaching
practical courses of Forensic Medicine
and Clinical Toxicology,
Faculty of Medicine, Cairo University.
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Teaching
practical courses of Forensic Medicine
and Clinical Toxicology,
Faculty of Medicine, October-6-University.
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Teaching Medical Ethics courses, Beni Suef
Faculty of Medicine, Beni Suef
University.
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Teaching
courses of
Forensic Medicine, nursing
department in applied medical sciences faculty, Beni Suef University.
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Actively
contributed in the establishment of the Poison Control Center in Beni Suef University Hospitals in Beni Suef
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Constructing plans, protocols for
master, doctrine degrees & for individual researches in my particular
field.
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Dealing efficiently with
experimental animals according to ethical regulations.
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Executing the protocols, collecting
data, performing measurements, reading results, & analyzing them.
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Performing biostatistics using the
SPSS- software statistical package.
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Collecting references & writing
papers. Reaching conclusions & setting recommendations.
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Discussing research work of
postgraduate students.
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Designed the program and the
courses for the degree of M. Sc. And M.D. in Forensic Medicine& Clinical Toxicology
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Participated In The
Supervision Of: (3) M.D. theses and (2)
M.Sc. theses
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Participated In
discussion many Essays & Theses for Masters and Medical Doctorate in
Forensic and Clinical Toxicology, Faculty of Medicine in various Egyptian
universities.
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Regular active
participant in the departmental scientific meetings (seminar), since 2003.
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Printed
Articles and Seminars:
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Uses
of voiceprints in medicolegal practice
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Toxicogenomics
& toxicogenetics
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Bloodstain
Pattern Analysis
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Drug Induced
Hepatitis
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Forensic
Serology and DNA Typing
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Sexual Offences
(crimes)
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systemic
response to trauma
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UPDATES IN
MANAGEMENT OF ORGANOPHOSPHORUS COMPOUNDS POISONING
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Virtopsy
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DNA forensic
analysis
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Biological effects of Ionizing
Radiation
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Chemical and Biological Warfare
Agents
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Gastrointestinal decontamination of poisoned adults
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Principles and Techniques Applied to Enhance Elimination
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Paracetamol Poisoning: Clinical Practice Guidelines
- Teaching
& practical Activities in clinical toxicology and forensic chemistry
, Dammam Regional Poison Control Center, KSA.
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Participation in Preparation
and implementation of protocols and policies in management of all types of
toxicology cases
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Participation in Preparation
and implementation of policies and procedures regarding the whole toxicology analytical process according to
the quality roles in each stage ( pre analytical –analytical and post analytical
)
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Participation in Preparation
and implementation of all regulations and policies regarding the working staff
( job descriptions – evaluation
–training – and evaluation of the training needs )
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Preparation and
implementation of policies of drug and information unit.
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Participation in new
methodology validations of pseudo cholinesterase detection in Architect
immunoassay
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Teaching courses of Clinical Toxicology and Forensic chemistry for Saudi Board of
forensic medicine .
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Participation in
curriculum mapping (practical and theoretical ) for saudi forensic board candidates
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Participation in
the weekly sintefic meeting of emergence
toxicology department.
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Participation in
the routine Toxicology investigation of the department, including forensic and
clinical cases.
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Participation in the
teaching activities and training of stuff member of emergency toxicology and
forensic chemistry departments: medical, law, sport and Postgraduate students.
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Lectures in poisoning and management in First aid course for
pharmacist
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Participation in Reviewing
and updating the A antidote list used in management of poisoning cases with
detailed description of( indications ,contraindications ,doses ,side effects –
and availability in KSA )
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Participation in Writing the test catalogue
regarding all the details for every test carried out in Dammam poison control
center linked to the international
(LOINC CODE)
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Effective
participation in Setting &
implementing the
electronic national project OTARR ( online toxicology analysis request and
result ) to join all the PCC all over the kingkdom by setting up and reviwing
the requests forms requirements for all the available services which include (
emergency toxicology – therapeutic drug monitoring – drugs of abuse – research
and confirmation – forensic medicine and water analysis )
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Effective
participation in establishement of the IVR system (interactive voice response)
and hot line management sysytem in DPCC
Attended Training Courses
in:
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Training Course and dealing with
different toxicological cases in Ain Shams PCC, Ain Shams University
(2006-2007)
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Training Course
in Forensic Dissection and Clinical Forensic Examination, In Higher Forensic
Dissection Home, Zeinhom Morgue of Forensic Medicine Institute, Cairo "
(2004-2005, 2010-2011)
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Attended a training
course on detection of drugs of abuse in biological samples in the Central
Labs. of the Ministry Of Health in 2010. The program of the courses included
theoretical and practical training on Thin Layer Chromatography (TLC),
Toxi-Lab. Drug Detection System, TDX, High Performance Liquid Chromatography
(HPLC), as well as, training on the conventional and recent extraction methods
as Solid Phase Extraction (SPE).
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Attended a training
course on "pediatric
toxicology : diagnosis and management" Aser Province Ministry of health,
KSA, ( 3-4/4/2012)
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Attended a training workshop in
" INTENSIVE CARE &EMERGENCY MEDICINE" in mouwasat hospital Dammam,
KSA, ( 2/2/2012)
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Speaker in 1st
therapeutic drug monitoring in Dammam poisoning control center , Eastern Province
Ministry of health, KSA, ( 1-5/9/2013)
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Speaker in 1st basics
of clinical toxicology in Dammam poisoning control center , Eastern Province
Ministry of health, KSA, (22-26/12/2013).
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Forensic
Science And Forensic Medicine Under An Education Microscope: What Does It Mean
To View Forensics From An Education Lens? Workshop, in the 6th
meeting of nMAFS Annual conference titled “Forensics Coming Home: Innovations
and Best Practices”, 8-10/3/2014
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Sexual
Assault Victims Examination / Evaluation & Reporting” “A Special Course For
Physicians” 2 Workshop, in the 6th meeting of nMAFS Annual
conference titled “Forensics Coming Home: Innovations and Best Practices”,
8-10/3/2014
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Attended a training course in Advanced Life Support in Sheikh
Zayed Hospital Egypt in 2008.
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Training
course in quality assurance in medical education, Faculty of Medicine, Cairo
University.
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Training
Courses in Methods of Teaching Faculty and Leadership Development Center (FLDC)
(22/2/2009 – 13/3/2009) Cairo University.
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Training
Course in Scientific Research Ethics from Faculty and Leadership Development
Center (FLDC) Cairo University.
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Training
Course in Conference Organization from Faculty and Leadership Development
Center (FLDC) Cairo University.
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Training
Course in University Staff Members` Code of Ethics from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in International Publishing Research from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in How to Compete For a Research Fund from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in Time and Meetings Management from Faculty and Leadership Development
Center (FLDC) Cairo University.
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Training
Course in Quality assurance protocols in teaching from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in Skills of effective presentation from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in Skills of effective communication from Faculty and Leadership
Development Center (FLDC) Cairo University.
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Training
Course in Scientific research methods from Faculty and Leadership Development
Center (FLDC) Cairo University.
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Training
Course in Financial and lawful aspects from Faculty and
Leadership Development Center (FLDC) Cairo University.
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Training
Course in Statistical &research methods from Faculty
and Leadership Development Center (FLDC) Cairo University.
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Training Course in E-Learning from Faculty
and Leadership Development Center (FLDC) (28-30/12/2009) Cairo University.
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Training Course in Research Ethics from Faculty
and Leadership Development Center (FLDC) (19-20/5/2013) Beni Suef University.
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Training
Course in University
Management from Faculty
and Leadership Development Center (FLDC) (22-23/5/2013) Beni Suef University.
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Training
Course in Effective
Presentation Skills from Faculty and Leadership Development Center (FLDC) (27-29/5/2013)
Beni Suef University.
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Training
Course in Managing
Time & Meeting from Faculty and Leadership Development Center (FLDC) (2-3/6/2013)
Beni Suef University.
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Training
Course in Quality
Standards in the Education Process from Faculty and Leadership Development
Center (FLDC) (4-5/6/2013) Beni Suef University.
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curriculum
mapping and intended learning outcome in National Authority for Quality
Assurance and Accreditation Of Education
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Training
in Methods of Research.
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Training
Courses in Management Skills.
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Training
Course in Hospital Management.
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Research Projects:
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Endogenous
Ethanol Production in resident of KSA: An attempt to advise on legal limits
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Medico-legal and forensic
implications of Endogenous ethanol production in
patients with Diabetes Mellitus in KSA.
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Sevoflurane
versus Isoflurane: Genotoxic effects in sperm and germ cell in albino rats
studied in vivo using the comet assay
Conferences and Scientific Symposium:
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Symposium on the medicolegal aspects of raped
cases on May/ 2005
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Symposium on the Islamic perspectives of
medical ethics on May/ 2005
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Symposium
on combating smoking & addiction from the medical, behavioural
psychological, social legal & religious perspectives on 18/ 12/ 2004
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The
fourth annual scientific conference & the first international medical
conference in the Faculty of Medicine – October 6 University held in Movenpick
hotel on 28/ 2/ 2004 & the graduation ceremony for the 2nd batch on 27/ 2/
2004
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Symposium
on the tie between medical ethics, medical jurisprudence & quality of
medical education in Sheraton El Gezira Hotel on 15/ 5/ 2005
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The 24th annual
conference of the Egyptian Society of Basic Medical Sciences held in the
conference center in Kasr El Aini on 14/ 4/ 2005
Symposium
on intensive care & emergency
medicine, 3rd Mouwasat Symposium ,17/12/2012
1st scientific conference entilted laboratory services in
clinical practice, KFMMC,KSA, 18-19/10/2011.
1st saudi international conference for forensic medical sciences,
Saudi Society of forensic medicine,KSA,
11-14/3/2012.
The 6th meeting of Mediterranean Academy of Forensics Sciences Annual conference
titled “Forensics Coming Home: Innovations and Best Practices”, 8-10/3/2014
Membership
of Scientific Organization:
Member in
Egyptian Association of Forensic Medicine and Toxicology since 2007.
Membership in Egyptian Society of Natural Toxins
since 2009.
Membership in Egyptian Society of Clinical Toxicology since 2012.
Membership in The Arab Union of Forensic & Toxicology(AUFT), AUFT Representative in
K.S.A.
Member of
The Egyptian Society Of Legal Medicine
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Membership in The International Association of Law and Forensic
Science (IALFS)
Member of the General Egyptian Medical Syndicate
Member of Saudi
commision for health specilites.
PUBLICATIONS:
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Mohamed A.
Noaishi, Mostafa M.M. Afify and
Samir H. Haggag. (2011): Analysis of P53 Gene Mutations in Peripheral Blood
Lymphocytes of Egyptian Spray Workers Exposed to Multiple Pesticides. Journal
of American Science 2011; 7(3):538-543]. (ISSN: 1545-1003). http://www.jofamericanscience.org/journals/am-sci/am0703/65_4864am0703_538_543.pdf
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Alaa A. Mecdad , Manal H. Ahmed , Manal E.A.
ElHalwagy ,Mostafa M.M. A?fy(2011): A study on oxidative
stress biomarkers and immunomodulatory effects of pesticides in
pesticide-sprayers, Egypt Egyptian Journal of Forensic
Sciences (2011)1, 93–98. http://www.sciencedirect.com/science/journal/2090536X/1/2
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Mohamed A.
Noaishi, Mostafa M.M. Afify and
Naglaa F.E. Mahmoud. (2011): Mutation Analysis of K-ras Gene in
Peripheral Blood Lymphocytes of Egyptian Workers Occupationally Exposed to
Multiple Pesticides. Journal of American Science 2011; 7(12):1025-1030]. (ISSN:
1545-1003).http://www.jofamericanscience.org/journals/am-sci/am0712/129_7913am0712_1025_1030.pdf
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Mostafa M. Afify, Naglaa F. Mahmoud, Ghada M. Abd El
Azzim, Nevein A. El Desouky (2012): Fatal burn
injuries: A five year retrospective autopsy study in Cairo city, Egypt Egyptian
Journal of Forensic Sciences (2012)2, 117–122. http://download.journals.elsevierhealth.com/pdfs/journals/2090-536X/PIIS2090536X12000470.pdf
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Mohamed A. Noaishi, Amr A. Abd Allah and Mostafa M.M. Afify (2013):
Oral and dermal exposure of chlorpyrifos and cypermethrin mixture induced
cytogenetic, histopathological damage and oxidative stress in rats. J Am Sci
2013;9(3):56-65]. (ISSN: 1545-1003). http://www.jofamericanscience.org/journals/am-sci/am0903/009_16164am0903_56_65.pdf
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Mohamed A.
Noaishi, Mostafa M.M. Afify and Amr
A. Abd Allah. (2013):
Study
the inhalation exposure
effect of pesticides mixture
in the white
rat. Nat Sci 2013;11(7):45-54].(ISSN:1545-0740).http://www.sciencepub.net/nature/ns1107/009_18671ns1107_45_54.pdf
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Alsaif D, Alsowayigh K, Alfaraidy M, Albayat M, Alshamsi G, Aldosary M, Madadin M, Afify M, Kharoshah M.
(2013): Child homicide
in Cairo from 2006 to 2010: characteristics and trends.
J Forensic Leg Med. 2013
Oct; 20(7):929-32
http://www.sciencedirect.com/science/journal/1752928X/20/7
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Mostafa M. Afify; Mohamed K. Zayet; Naglaa F.
Mahmoud; Ahmed R. Ragab
(2014):
Age Estimation from Pulp/Tooth Area Ratio in Three Mandibular Teeth by
Panoramic Radiographs: Study of an Egyptian Sampl. J Forensic Res 2014, 5:3. http://omicsonline.org/open-access/age-estimation-from-pulptooth-area-ratio-in-three-mandibular-teeth-by-panoramic-radiographs-study-of-an-egyptian-sample-2157-7145.1000231.pdf
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Ahmed R. Ragab; Omar Farouk; Mostafa M.
Afify; Afaf M. Attia; Ayman El Samanoudy; Yasmeen M.
Taalab (2014): The Role of Oxidative Stress in Carcinogenesis Induced By Metals
in Breast Cancer Egyptian Females Sample
at Dakahlia Governorate. J Environ Anal Toxicol2014, 4:2 http://omicsonline.org/environmental-analytical-toxicology.php
Computer skills & Spoken languages:
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ICDL, 2010, Cairo
University, Egypt.
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Training Course in "Word,
Excel and Power Point Microsoft Office, Internet, 2006, Cairo University,
Egypt.
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Spoken languages:
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Arabic-Degree:
Excellent.
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English-Degree:
Excellent.
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Succeeded
in TOEFL Test in Cairo University Center for Foreign Languages and Professional
Translation 7/2004.
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French-Degree:
Good.
Master Title
Medicolegal view of Malpractice crisis IN Obstetrics and gynecology
Master Abstract
The malpractice crisis became a famous problem in the last years, where the obstetricians and gynecologists have been particularly affected by the increase in the cost and numbers of medical malpractice claims in Egypt. There are three social goals of malpractice litigation: to deter unsafe practices, to compensate persons injured through negligence and to exact corrective justice. The malpractice crisis has had significant impact on obstetricians, gynecologists and the women who seek their services. The aim of this study is to detect the causes of medical malpractice such as professional negligence, professional misconduct and prevention of it.
PHD Title
Age Dependent Immunomodulation, Genotoxicity and Oxidative Stress due to Pesticide Mixture Exposure and Protective Potential of Antioxidants in Albino Rats
PHD Abstract
This thesis was designed to study dose-related and age-related effects of the mixture of four pesticide residues extract (chloropyrifos, profonofos, fenitrothion and dicofol) on Oxidative Stress, Genotoxicity and immunotoxicity, and Protective Potential of natural Antioxidants (garlic 250 mg/kg and alpha lipoic acid 60mg/kg), 120 males of Albino rats will be divided into two main groups according to age; weaning group (2 months age) and Adult group (6 months age). Each age group of rats were divided into 6 subgroups (10 rats in each) the 1st group served as control, the 2nd&3rd groups were orally treated with high & low level of pesticides residue mixture, respectively, the 4th group served as +ve control (antioxidants only), the 5th &6th groups were orally treated with antioxidants 1h after administration of high & low level of pesticides residue mixture, respectively, All groups were force-fed by gastric intubations 5 days per week for 3 months. The oxidative stress status of treated animals has been evaluated by assessment of reduced glutathione (GSH), Glutathione-S-Transferase (GST), malondialdehyde (MDA). In addition, the acetylcholinesterase (AChE) activity was measured as a biomarker of toxicity. The mean comet tail length and Comet DNA % were used to measure DNA damage. We used IgG, IgM, rate of leucocyte phagocytosis and of lymphocyte transformation as immunotoxicological biomarkers to test the immune function as well as Histopathological studies in lymph node. Our result revealed that pesticide mixture induce inhibitory effect on AChE, depletion in GSH content, alteration in GST and elevation in lipid peroxidation (MDA). A significant increase in mean comet tail length and Comet DNA % indicating DNA damage was observed. The damage was dose related. The results showed that pesticides mixture produced a decrease in Both IgG and IgM, the rate of lymphocyte transformation and the rate of leucocyte phagocytosis also decrease in both age groups. In additions, our result revealed that natural antioxidants (ALA and garlic extracts) have more or less counteracting effect on Oxidative Stress, Genotoxicity and immunotoxicity caused by pesticides.