Basic Informations
C.V
Personal Data:
Name: Asmaa Gamal Safi El-din
Nationality: Egyptian.
Telephone: 01061220100.
E-mail: fut_med_as@yahoo.com
Current Mailing Address: Medicinal Chemistry Department, Faculty of Pharmacy Beni-Suef University.
Current Appointment: Assistant Lecturer of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, present.
Education
B. Sc. Pharmacy and Pharmaceutical Sciences, Beni-Suef University (excellent honor) June 2009.
M. Sc. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Beni-Suef University, December 2015, entitled: “Synthesis of diarylheterocyclic derivatives as analgesic and anti-inflammatory agents”.
Professional Appointments:
Demonstrator in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Beni-Suef University 2010-2015.
Assistant Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, 2015-present.
Master Title
Design,synthesisandBiologicalEvaluationofNovel Diaryl-heterocyclicderivativesasPotentialAnalgesics andAnti-inflammatoryAgents
Master Abstract
In the present work, design and synthesis of several substituted diarylthiazole VIIIa,b and IXa-h, diarylimidazole XIIa,b and XIIIa-h, thiazolidinone XVI-XX and XXIV-XXVIII were discussed. The rational for these compounds was discussed. Characterization of the chemical structure of the new compounds was done using spectral and elemental analyses. Evaluation of the anti-inflammatory and analgesic activity of the new compounds was performed by determination of the percentage of inhibition of edema for anti-inflammatory activity and number of writhing for analgesic activity. The most potent diarylthiazole compounds were VIIIa,b with IC50 of 4.21 µM and 4.56 µM against COX-1 respectively. The most potent diarylimidazole compounds were XIIa,b with IC50 of 6.32 and 7.09 µM against COX-1 respectively
PHD Title
DESIGN,SYNTHESISANDBIOLOGICALEVALUATIONOFNEWDIARYL-HETEROCYCLICDERIVATIVES OFANTICIPATEDPHARMACOLOGICALACTIVITY.
PHD Abstract
In the present work, design and synthesis of novel diaryl pyrazole or 1,2,4-triazole bearing either carboxamide or uredio or 1,3,4-oxadiazole heterocyclic derivatives VIIa-f, XIa-f, XVIa-e, XXIa-f and XXIIa-d have been discussed. The chemical structures of the new compounds were characterized using spectral and elemental analyses. The newly synthesized compounds were evaluated for their in vivo anti-inflammatory/analgesic activities compared to celecoxib. In addition to, COXs and sEH inhibitory assay relative to celecoxib and AUDA. Finally, docking studies were performed for certain compounds to strengthen our rational.