Basic Informations
C.V
Address:Fayoum
Date of Birth 2/16/1993
Place of Birth
Fayoum
Gender Female
Nationality Egyptian
Marital status married
Religion Muslim
ID
E-mail:
Yassokhaled280@yahoo.com
yasmin.abdelaleem@pharm.bsu.edu.eg
EDUCATION & ACADEMIC QUALIFICATIONS: -
Bachelor degree in Pharmaceutical science, Faculty of Pharmacy Beni-suef University, year 2014 with Excellent with honour grade.
Master Degree in pharmaceutics, Faculty of pharmacy – Beni-Suef University – Jan 2020. The master thesis was entitled
‘’A pharmaceutical study on Novel Drug Delivery System of Lercanidipine HCL for Treatment of Hypertension’’
CURRENT POSITION AND CAREER
Assistant lecturer at pharmaceutical department, Faculty of Pharmacy, Beni-SuefUniversity
Language:
Arabic (Mother tongue),
English (Excellent)
CAREER SUMMARY: -
Working as a Demonstrator from 2015 till 2020Master Title
''A pharmaceutical study on Novel Drug Delivery System of Lercanidipine HCL for Treatment of Hypertension''
Master Abstract
Poor bioavailability of drugs via oral route is the greatest challenge facing drug formulation. To overcome this obstacle, transdermal route was commonly used as an alternative route to improve bioavailability. Lercanidipine HCL (LER) is a vasoselective calcium-channel blocker that has a poor oral bioavailability of 10% due to its hepatic metabolism and low aqueous solubility. The main objective of this study was to develop nanoethosomal LER gel for transdermal delivery to increase its skin permeation and promote bioavailability. Nanoethosomes were prepared and optimized using a Box–Behnken design employing ethanol injection method. The design studied the influence of Phospholipon 90G(PL90G), LER and ethanol concentrations on entrapment efficiency (EE%); vesicle size; % cumulative LER release (CLERR) and cumulative LER permeated per unit area at 24 h Q24 (µg/cm2). The pharmacokinetic parameters of the optimized formulation were determined in rats. Nanoethosomes showed a mean vesicle size between 210.87 and 400.57 nm and EE% ranging from 49.26 to 97.22%. The developed Nanoethosomes enhanced % CLERR and Q24 values compared to drug suspension. The experimental parameters of optimized formulation were very close to those calculated by software. The pharmacokinetics study showed three times statistically significant (p < 0.05) enhancement in LER bioavailability following nanoethosoml LER gel transdermal application compared to that of oral LER suspension. Nanoethosomes can be considered as a promising carrier for LER transdermal delivery, thus will be fruitful therapy in hypertension management.
PHD Title
PHD Abstract