Basic Informations
C.V
- Mobile: 00971 50 6628465
- Email : lourinnasr@yahoo.com
- Date of Birth: 09/10/1988
- Place of Birth: Egypt
- Gender: Female
- Nationality: Egyptian
- Material Status: Single
- Place of Residence: United Arab Emirates
- Address Abu Dhabi
- Education & Qualification
- University Degree master Degree of Pharmacy
- University Bani-Swif University – Egypt
- Graduation Year 2011
- Overall Grade 94% - (A) Grade
- High School Degree 12 Grade
- Total Grade 98%
- School Rosary School – Abu Dhabi
- From June 2012 up to now
- Work as an assistant lecturer in biochemistry department in Faculty of Pharmacy Bani-Suef University (Formerly Cairo University Bani-Suef Branch)
- Skills
- Computer Skills
- Excellent knowledge of Windows application.
- Good knowledge of MS office applications
- Good knowledge of Internet
- Language Skills
- Arabic Native Language
- English Very Good command of written & Spoken English
- Interpersonal (soft) Skills
- Very good command of communication skills
- Quick learner and self motivated
Available documents ready for submission
- High School Certificate
- University Degree Certificate
- Credit Hours Certificate
- ICDL Certificate
- IELTS Certificate
- UAE Driving License
Master Title
Role of Balanites aegyptiaca on SAPK-JNK pathway in diabetic rats' model
Master Abstract
Abstract
SAPK-JNK pathway performs a significant role in the pathogenesis of type 2 diabetes. Balanites aegyptiaca (BA) is used as an anti-diabetic agent in folk medicine however; its hypoglycemic mechanism is not fully elucidated. The current study aimed to evaluate the effect of crude extract, butanol, and dichloromethane fractions from BA on the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK-JNK) pathway in experimental diabetic rats. Six groups of male Wistar rats were included: normal control, diabetic, diabetic rats treated with crude, butanol or dichloromethane fraction from BA (50 mg/kg BW) and diabetic rats treated with gliclazide as a reference drug for one month. Our results suggested a protective role of treatment of diabetic rats with BA against oxidative stress-induced SAPK-JNK pathway. Moreover, BA treatment produced a reduction in plasma glucose, HbA1c, lactic acid, lipid profile, malondialdehyde levels and produced an increase in insulin, reduced glutathione levels, catalase and superoxide dismutase activities compared with untreated diabetic rats. Moreover, it decreased apoptosis signal-regulating kinase 1, c-Jun N-terminal kinase 1, protein 53 and increased insulin receptor substrate 1 in rat pancreas while it increased glucose transporter 4 in rat muscle. Analysis of BA extracts by LC-HRMS revealed the presence of different saponins with reported hypoglycemic effect. In conclusion, BA exerted hypoglycemic, hypolipidemic, insulinotropic and antioxidant effects. Additionally, it reduced apoptosis in pancreatic ß-cells and increased glucose uptake in muscle. These results suggest that the hypoglycemic effect of BA is due to the inhibition of the SAPK-JNK pathway.
Key words: Balanites aegyptiaca, Diabetes, SAPK-JNK pathway, Oxidative stress,.Apoptosis
PHD Title
Role of Balanites aegyptiaca on SAPK-JNK pathway in diabetic rats' model
PHD Abstract
Abstract
SAPK-JNK pathway performs a significant role in the pathogenesis of type 2 diabetes. Balanites aegyptiaca (BA) is used as an anti-diabetic agent in folk medicine however; its hypoglycemic mechanism is not fully elucidated. The current study aimed to evaluate the effect of crude extract, butanol, and dichloromethane fractions from BA on the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK-JNK) pathway in experimental diabetic rats. Six groups of male Wistar rats were included: normal control, diabetic, diabetic rats treated with crude, butanol or dichloromethane fraction from BA (50 mg/kg BW) and diabetic rats treated with gliclazide as a reference drug for one month. Our results suggested a protective role of treatment of diabetic rats with BA against oxidative stress-induced SAPK-JNK pathway. Moreover, BA treatment produced a reduction in plasma glucose, HbA1c, lactic acid, lipid profile, malondialdehyde levels and produced an increase in insulin, reduced glutathione levels, catalase and superoxide dismutase activities compared with untreated diabetic rats. Moreover, it decreased apoptosis signal-regulating kinase 1, c-Jun N-terminal kinase 1, protein 53 and increased insulin receptor substrate 1 in rat pancreas while it increased glucose transporter 4 in rat muscle. Analysis of BA extracts by LC-HRMS revealed the presence of different saponins with reported hypoglycemic effect. In conclusion, BA exerted hypoglycemic, hypolipidemic, insulinotropic and antioxidant effects. Additionally, it reduced apoptosis in pancreatic ß-cells and increased glucose uptake in muscle. These results suggest that the hypoglycemic effect of BA is due to the inhibition of the SAPK-JNK pathway.
Key words: Balanites aegyptiaca, Diabetes, SAPK-JNK pathway, Oxidative stress,.Apoptosis