Basic Informations

C.V

Curriculum Vitae of Dr/Mohamed T. Elsdaadi

Personal Data

Name: Mohammed Taha El-Saadi

Nationality: Egyptian.

Telephone: 01028725954 - 01144695905.

E-mail: Moh1­­­_ttaha@yahoo.com., Mohamed.elsaadi@pharm.bsu.edu.eg            

Current Mailing Address: Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy   Beni-Suef University.

Current Appointment: Associate professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, present. 

 

Education 

  • B. Sc. Pharmacy and Pharmaceutical Sciences, Beni-Suef University (excellent honor) June 1999.
  • M. Sc. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Cairo University, Septemper 2006, entitled: “Synthesis of Some Fused Pyrimidine Derivatives of Anticipated COX Inhibitory  Activity”.
  • Ph. D. Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Beni-Suef University, Jul 2009, entitled: “Synthesis of some pyrimidine derivatives of potential anti-inflammatory activity.

Professional Appointments

  • Demonstrator in Pharmaceutical Chemistry Department, Faculty of Pharmacy, Beni-Suef University 2000-2006.
  • Assistant Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef University, 2006-2010.
  • Lecturer of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef, 2010- 2017.
  • Associate professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni-Suef, 2017- present.

Training courses and workshops

  • Quality standards in the educational process
  • Ethics of scientific research
  • International publication of scientific researches
  • Strategic planning
  • Financial and legal aspects in university.
  • Organizing scientific conferences
  • Computer aided drug design using MOE software.[Faculty of Pharmacy - Assuit University].
  • Recent advances in chemistry and biology of natural products[ Faculty of Pharmacy - Beni-Suef University]Learning and active learning strategies. [ Faculty of Pharmacy - Beni-Suef University]
  • Academic standards that meet the specifications of the graduate. [ Faculty of Pharmacy - Beni-Suef University]

Meetings and Conferences

  • 1st international conference on advanced basic and applied sciences(ABAS)
  • 1st undergraduate final year conference
  • 1st International Conference on Health between Nutrition and Treatment

Funded reasearch projects

 

  • CO-PI in "Design, Synthesis and anticancer activity evaluation of new benzothiazole derivatives with potential as EGFR inhibitors". Grant from Research Center, Beni-Suef Univeristy.
  • CO-PI in "Synthesis of certain heterocyclic compounds of certain biological activity". Grant from Research Center, Beni-Suef Univeristy.
  • CO-PI in " Design, synthesis and biological evaluation of novel indomethacin derivatives as anti-inflmmatory agents with low ulcerogenicity." Grant from Science and Technology Development fund [STDF].

Teaching activities

Undergraduate level.

Pharmaceutical Chemistry department, Faculty of pharmacy, Beni-Suef university:

  • Participation in teaching and supervising the practical work of pharmaceutical chemistry 1 course (801) for fourth year students since 2011.
  • Participation in teaching and supervision of the practical work of pharmaceutical chemistry 1 course I (PC509) for students of the clinical pharmacy program (fourth level) since 2011.
  • Participation in teaching and supervising the practical work of pharmaceutical chemistry 2 course (802) for fourth year students since 2011.
  • Participation in teaching and supervision of the practical work of pharmaceutical chemistry 2 course (PC610) II for students of the clinical pharmacy program (fourth level) since 2011.
  • Participation in teaching and supervising the practical work of pharmaceutical chemistry 3 (803) for students of the fifth year since 2011.
  • Participate in teaching of drug design Elective course for students of the fifth year since 2011.
  • Participate in teaching the drug synthesis elective course for students of the fifth year in 2015.

Pharmaceutical Chemistry department, Faculty of pharmacy, NUB University:

  • Participate in teaching and supervision of the practical work of pharmaceutical chemistry I course. for the academic year [2o13 / 2014-2015 / 2016] (the first semester).
  • Participate in teaching and supervising the practical work of pharmaceutical chemistry II in Faculty for the academic year [2013 / 2014-2014/2015] (the first semester).
  • Participate in the teaching and supervision of practical work of pharmaceutical chemistry III for the academic year [2014/2015 - 2015/2016] (first semester - the second semester).

Postgraduate level.

 

  • Participation teaching the "Drug design" course for students of the Masters since 2013.
  • Participation in teaching "Advanced topics in medical chemistry" course for students of the Masters since 2013.
  • Participation in teaching "Spectroscopic and chromatographic techniques" course for students of the Masters since 2013

Other teaching activities:

  • Partner in oral exam committees, Faculty of Pharmacy, Beni-Suef , El-Minia, Cairo Assuit, Nahda and 6-October universities.
  • Sharing the stuff members of pharmaceutical chemistry department in the preparation of note books for the theoretical and practical curricula for the fourth and fifth year students at the Faculty of Pharmacy Beni-Suef.
  • Participate in the work of examinations, which include monitoring within the committees and the development and correction of examinations.
  • An academic advisor for students of different grades in the clinical pharmacy program since 2012.
  • Supervising the summer training for students of Beni Suef University since 2012.
  • Supervising the graduation projects for fifth year students in 2014-2015

List of Publication

       1.           El-Sayed NA, Farag, AE, El-Saadi MT, El-Moghazy SM, and Abd Ellatif HA, “Synthesis and anti-inflammatory activity of some fused pyrimidines ”, Bull Pharm Sci Assuit Univ, 29, 520-546- (2006).

       2.           El-Sayed NA, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohamed T. EL-Saadi; ‘’Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido[1,6-a]azepine derivatives’’, Eur. J. Med. Chem. 45 (2010) 3147–3154.

       3.           El-Sayed NA, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohamed T. EL-Saadi; Potential anti-inflammatory activity and ulcerogenicity study of some novel pyrimido[4l,5l:4,5]pyrimido[1,6-a]azepine derivatives". Med. Chem. Res.(2011)

       4.           Ahmed H. Abelazeem, Shimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar,     Christopher R. McCurdy, Samir M. El-Moghazy; "Novel pyrazololpyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents". Eur. J. Pharm. Sci. 62 (2014) 197-211.

       5.         Ahmed H. Abelazeem, Mohammed T. El-Saadi, Asmaa G. Safi El-Din, Samir M. El-Moghazy.  ''Design, synthesis and biological evaluation of novel diphenylthiazole-thiazolidin-4-one-based derivatives as anti-inflammatory/analgesic agents''. Journal of chemical and pharmaceutical research. 7(7), 2015, 1073-1079.

       6.         Ghaneya S. Hassana, Fadi M. Awdallaha, Mohammed T. El-Saadi, Ahmed O. Elgendic and Loah R. Hemeda. " Synthesis of some benzothiazole derivatives evaluated as antimicrobials and antibiofilms". Journal of chemical and pharmaceutical research. 7(7), 2015, 1125-1143.

       7.         Khaled R. A. Abdellatif, Mohammed T. Elsaady, Salah A. Abdel-Aziz, and Ahmed H. A. Abusabaa. " Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore". Journal of enzyme inhibition and medicinal chemistry. 7(7), 2015, 1125-1143.

       8.         Nagwa M. Abdel Gawad , Noha H. Amin , Mohammed T. Elsaadi , Fatma M. M. Mohamed , Andrea Angeli , Viviana De Luca , Clemente Capasso , Claudiu T. Supuran. " Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines" . Bioorganic and medicinal chemistry. 24, 2016, 3043-3051.

       9.         Ahmed H. Abdelazeem , Mohammed T. El-Saadi , Asmaa G. Safi El-Din , Hany A. Omar, Samir M. El-Moghazy. " Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile." Bioorganic and medicinal chemistry. 25, 2016, 665-676.

     10.       Mohammed T. Elsaadi, Ahmed M. Gouda, Fadwa H. Edrees and Nagwa M. Abdel Gawad. "Design,synthesis and biological evaluation of some novel Schiff base derivatives as potential anticancer agents."  Journal of chemical and pharmaceutical research. 8(5), 2016, 273-282..

     11.       Martha M.Morcoss, Nada S.Abdelwahab, Nourddin W.Ali, Mohammed T. Elsaadi. " Different chromatographic methods for simultaneous determination of diloxanide furoate, metronidazole and its toxic impurity." Journal of the Iranian Chemical Society. 13, 2016, 1643-1651.

     12.       Martha M.Morcoss, Nada S.Abdelwahab, Nourddin W.Ali, Mohammed T. Elsaadi. " Different Spectrophotometric and TLC-Densitometric Methods for Determination of Mesalazine in Presence of Its Two Toxic Impurities." Chemical and pharmaceutical bulletin. 64, 2016, 1268-1274.

     13.       Martha M.Morcoss, Nada S.Abdelwahab, Nourddin W.Ali, Mohammed T. Elsaadi. " Different Spectrophotometric Methods for Determination of Mefenamic Acid in Presence of its Two Toxic Impurities." Analytical Chemistry Letters. 13, 2016, 913-920.

     14.       Martha M.Morcoss, Nada S.Abdelwahab, Nourddin W.Ali, Mohammed T. Elsaadi.             " Spectrophotometric determination of metronidazole, diloxanide furoate and metronidazole toxic impurity."  Journal of chemical and pharmaceutical research. 15, 2016, 112-123.

     15.       Nada S Abdelwahab, Mohammed T Elsaady, Aml G Korany, Maha A Hgazy. "Determination of Dantrolene Sodium in the Presence of its Process-Related Impurity by High-PerformanceThin-Layer Chromatography- Spectrodensitometry." JPC-Journal of Planar Chromatography-Modern TLC. 29(6), 2016, 462-468.

     16.       Khaled R. A. Abdellatif, Mohammed T. Elsaadi, Salah A. Abdel-Aziz, and Ahmed H. A. Abusabaa. "Synthesis, Anti-inflammatory and Molecular Docking Study of Schiff Bases Containing Methanesulphonyl Pharmacophore." Letters in Drug Design & Discovery. 14(8), 2017(8), 930-937.

     17.       Eman G. Said, Mohammed T. Elsaadi, Ahmed H. Abdelazeem, Samir M. El-Moghazy. "Exploring the Anticancer and Anti-Inflammatory Activities of Novel Diphenylthiazole-Amino Acid Conjugates." Journal of Applied Pharmaceutical science. 7(07), 2017[7], 212-217.

     18.       Eman G. Said, Mohammed T. Elsaadi, Ahmed H. Abdelazeem, Bahaa GM Youssif, Hany A Omar, Samir M. El-Moghazy. " Novel Diphenylthiazole derivatives with Multi-Target Mechanism: Synthesis, Docking study, Anticancer and Anti-Inflammatory Activities." Bioorganic Chemistry. 75, 2017(12), 127-138.

     19.       Nada S Abdelwahab, Mohammed T Elsaadi, Aml G Korany, Maha A Hegazy.                     "Study of gliquidone degradation behavior by high-performance thin-layer chromatography and ultra-performance liquid chromatography methods." Biomedical Chromatography. 31 (12), 2017(12), e4025.

     20.       Khaled R. A. Abdellatif, Mohammed T. Elsaadi, Noha H. Amin, Ahmed A. Hefny. " Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors." Journal of Applied Pharmaceutical science. 7(08), 2017[8], 069-077.

     21.       Ahmed I. Khodair, Mostafa M. Elbadawi, Mohammed T. Elsaadi, Khaled R. A. Abdellatif. " Design, Synthesis, Molecular docking and Cytotoxicity evaluation of some Novel 5-arylidene-3-(substituted phenyl)-2-(p-tolylamino)-4-imidazolones." Journal of Applied Pharmaceutical science. 7(09), 2017[9], 058-068.  

     22.       Shaimaa A. Abdelatef, Mohammed T. Elsaadi, Noha H. Amin, Ahmed H. Abdelazeem, Khaled R. A. Abdellatif. " Synthesis and Anticancer Screening Of Novel Spiro[Chromaffin-2,4'-Piperidin]-4-one Derivatives With Apoptosis-Inducing Activity." Journal of Applied Pharmaceutical science. 8(01), 2018[1], 009-016.

     23.       Nada S. Abdelwahab, Nouruddin W. Ali, Marco M. Zaki, M. AbdelKawy, Mohammed T. Elsaadi. " Quantitative Determination of Synthesized Genotoxic Impurities in Nifruroxazide Capsules by Validated Chromatographic Methods." International Journal of AOAC. 101 (2), 2018(3), 385-393.

     24.       Noha H. Amin,  Mohammed T. Elsaadi, Ahmed A. Hefny, Ahmed H. Abdelazeem, Heba AH. Elshemy, Khaled R. A. Abdellatif. " Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity." Future medicinal chemistry. 8, 2018, 235-249.

     25.       Shaimaa A. Abdelatef, Mohammed T. Elsaadi, Noha H. Amin, Ahmed H. Abdelazeem, Hany A. Omar,  Khaled R. A. Abdellatif. " Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities." European journal of medicinal chemistry. 150, 2018, 567-578.

     26.        Khaled R. A. Abdellatif, Mostafa M. Elbadawi, Mohammed T. Elsaadi, Amer A. AbdEl-Hafeez, Takashi Fujimura, Seiji Kawamoto, Ahmed I. Khodair. " Design, Synthesis and Cytotoxicity Evaluation of new 3,5-Disubstituted-2-Thioxoimidazolidinones." Anti-Cancer Agents in Medicinal Chemistry. 18(4), 2018(4), 573-582.

  University and community activities

  • Served as deputy director of Quality assurance Unit from October 2011 to October 2014
  • Member of the drafting committee of the strategic plan in the faculty
  • Member of the committee supervising the elections of the college students union in 2012-2013
  • Financial manager of NMR Lab from September 2013 to November 2015.
  • Contribution to the preparation of the financial and administrative list of the Consultation Center, Faculty of Pharmacy, Beni-Suef University
  • Participated in the organization of the first conference of the College of Pharmacy under the title "Health between nutrition and treatment", August 2015
  • Member of the technical committees for tenders held in the college since 2014.
  • Member of the General Syndicate of Pharmacists of Egypt since 1999.

C.V PDF

Master Title

Synthesis of Some Fused Pyrimidine Derivatives of Anticipated COX Inhibitory Activity

Master Abstract

a new series of pyrimido[1,6-a]azepine derivatives (I,II) substituted in the polymethylene ring by a morpholine or piperidine moiety were synthesized according to a known procedures. Additionally, the tricyclic pyrimido[4/,5/:4,5]pyrimido[1,6-a]azepine derivatives (III) were synthesized through acylation of the corresponding enaminonitriles (II) using chloroacetyl chloride, oxalyl chloride, and 4-chlorobuteryl chloride. Finally, the tetracyclic pyrrolo[2”,1”:2’,3’] pyrimido[4/,5/:4,5] pyrimido[1,6-a]azepine derivatives (IV) were synthesized through refluxing the corresponding tricyclic counterparts with different amine. The anti-inflammatory activity of 18 newly synthesized derivatives was evaluated using diclofenac-Na as standard drug. It was found that all the evaluated derivatives have significant activity at P<0.05 and also 4 derivatives showed potential anti-inflammatory activity compared with the standard drug. Molecular modeling and SAR study was carried out to correlate the influence of structure changes on the activity.

Master Abstract PDF

PHD Title

Synthesis of some pyrimidine derivatives of potential anti-inflammatory activity

PHD Abstract

New series of pyrimido[1,6-a]azepines were prepared through reaction of the key amino compound 4 with various reagents to give a variety of 3-N-substituted amino derivatives 5-13. The synthesized compounds included the Mannich bases 5a-c, the formimidic acid ester 6, the phenylformamidines 7a-c, the benzylidine amino derivatives 8a-c, the acetic acid derivatives 9, 10a-c and 11, the carbamoylformates 12a,b and the amides 13a,b. All compounds were screened for their anti-inflammatory activity using the carrageenan-induced paw oedema in rats using diclofenac sodium as reference drug. In addition, ulcer indices for the most active compounds were calculated. Compounds 3, 4, 8a,c, 11 and 12a,b showed activity similar to or higher than diclofenac sodium with no or minimal gastric ulceration. The most active compound with no ulcerogenic effect is the amino derivative 4 (IC 50 = 6.61 mmol/kg)

PHD Abstract PDF

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