Basic Informations
C.V
Address:
Beni-suef
Date of Birth
11/11/1990
Place of Birth:
Beni-suef
Gender:
Female
Nationality:
Egyptian
Marital status:
Married
Religion:
Muslim
ID:
29011112201581
E-mail:
hadeer.safwat@yahoo.com
hadeersafwat@pharm.bsu.edu.eg
EDUCATION & ACADEMIC QUALIFICATIONS: -
Bachelor degree in Pharmaceutical science, Faculty of Pharmacy Beni-suef University, year 2012.
CURRENT POSITION AND CAREER
Language:
Arabic (Mother tongue),
English (Excellent)
Demonstrator at Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University
CAREER SUMMARY: -
Working as a demonstrator from 2013 up to now
.
TEACHING EXPERIENCE:
Courses of Clinical Pharmacy Department - Faculty of Pharmacy - Beni-Suef University including:
- Gastroenterology (fifth year – level 10)
- Paediatrics (fifth year – level 10)
- Clinical Pharmacy (fifth year - general)
- Clinical pharmacy 2 (fourth year- level 8)
ACADEMIC AND OTHER ACTIVITIES:
.
PEER REVIEWD RESEARCH PUBLICATIONS:
- Harb, H. S., A. A. Elberry, H. Rabea, M. Fathy and M. E. Abdelrahim (2017). "Is Combihaler usable for aerosol delivery in single limb non-invasive mechanical ventilation?" Journal of Drug Delivery Science and Technology 40: 28-34. https://doi.org/10.1016/j.jddst.2017.05.022.
- Harb, H. S., H. Rabea, M. Fathy, A. A. Elberry and M. Abdelrahim (2017). "Combihaler vs t-piece for aerosol delivery in single limb non-invasive mechanical ventilation." Journal Of Aerosol Medicine And Pulmonary Drug Delivery 30 (3): 2-3. Presented as poster in the 21st International Society for Aerosols in Medicine (ISAM) Congress, Santa Fe, NM, 2017(3th June -7th June). https://doi.org/10.1089/jamp.2017.ab01.abstracts.
Conferences, Workshops And Courses Attended
- The 56th International Congress of The Egyptian Society of Chest Diseases and Tuberculosis the 28 th Conference of Middle East Region International Union Against Tuberculosis & Lung Diseases 24th – 27th March , 2015, Cairo, Egypt
- Critical care workshop in the 56th International Congress of the Egyptian Society of Chest Diseases and tuberculosis the 28 th Conference of Middle East Region International Union Against Tuberculosis & Lung Diseases 25th – 27th March , 2015, Cairo, Egypt
PRESENTATIONS
PROFESSIONAL MEMBERSHIPS
REFERENCES
Master Title
In-vitro and in-vivo study of the effectiveness of a new inhalation chamber for salbutamol delivery to non-invasive mechanically ventilated patients
Master Abstract
Background: Combihaler could connect both pressurized metered dose inhalers (pMDIs) and nebulizers to non-invasive ventilation (NIV) circuit. This can be used to give the patient a preliminary bronchodilator dose in an attempt to increase forced expiratory volume in one second pre-nebulization.
Aim of the work was to study the effectiveness of combihaler in salbutamol delivery with and without a preliminary bronchodilator dose compared with aerogen standard adult t-piece in single-limb NIV.
Methods: In-Vitro: Two milliliters of salbutamol solution (10000 µg) were nebulized using aerogen solo nebulizer (SOLO) with three connection setting; I: t-piece, II: combihaler and III: combihaler with pMDI. Only with connection III, two pMDI doses, containing 100 µg salbutamol each, were actuated pre-nebulization. Fate of nebulized dose was determined together with aerodynamic characteristics by anderson cascade impactor. In-vivo and Ex-vivo: Twelve NIV chronic obstructive pulmonary disease patients were included in six days urinary pharmacokinetic study in which 1 ml salbutamol solution (5000 µg) was nebulized using SOLO with the three connection settings randomized in days 1, 3 and 5 of the study. Only with connection III, the preliminary bronchodilator dose (200 µg salbutamol through pMDI) was given pre-nebulization. Urine samples were collected 30 min and pooled for 24 hr post-dose and extracted through solid phase extraction. At days 2, 4 and 6; ex-vivo study was carried out. All samples were analyzed using high performance liquid chromatography.
Results: No significant difference was found in-vitro in the fate of nebulized dose between the three connections. However, combihaler with pMDI had significantly greater fine particle dose less than or equal 5 µm as percentage of nominal dose and mass median aerodynamic diameter than both t-piece and combihaler without pMDI. However, t-piece had significantly higher fine particle fraction less than or equal 3 µm than both combihaler connections (II and III). No significant difference was found between the three connections for in-vivo and ex-vivo results which showed that combihaler with pMDI achieved the highest salbutamol fractions on both ex-vivo filters and lung bioavailability (urinary salbutamol 30 min post-dose). However, t-piece had the lowest body bioavailability (urinary salbutamol 24 hr post-dose).
Conclusion: T-piece and combihaler are equally efficient for salbutamol delivery from SOLO in single-limb NIV. However adding a preliminary bronchodilator dose pre-nebulization was found to alter aerodynamic characteristics to a significant level and optimizes the inhaled salbutamol fraction delivered to lungs to a statistically non-significant level.
Keys words: Salbutamol; NIV; COPD; SOLO; Combihaler; T-piece; pMDI; Preliminary bronchodilator dose; Lung; bioavailability.
PHD Title
PHD Abstract