CURRICULUM VITAE
:PERSONAL DATA
? Name: Fatma El-zahraa Abd-Elmonaem Mohamed Mohamed
? Address in Egypt: 15 Street Beni-Suef Elgedeeda, Beni-Suef, Egypt
? Marital status: Married
? Religion: Muslim
? Date of birth: 12/6/1982
? Nationality: Egyptian
? Driving License: Egyption Driving License
? Mobile No. 00201003330738
? E-mail : Fatmagendy@yahoo.com
:LANGUAGE
? Arabic: Native
(? English: Very good command (speaking, reading, and writing
:EDUCATION
? 1999-2004 B.Sc. of pharmacy, Faculty of Pharmacy, Beni-Suef University, Egypt
? Jan 2016 : Master of Pharmaceutical organic chimestry , Faculty of Pharmacy, Beni-Suef University
:EXPERIENCE
? 2005 till now : Demonstrator of pharmaceutical organic chemistry, Faculty of Pharmacy, Beni-Suef University
:TRAINING AND COURSES
? ICDL certificate
:INTERESTS
Music, running, swimming and computer
Abstract
This thesis comprises of four chapters. The first one is an introduction which consists of a brief literature survey of synthesis, pharmacological and cytotoxic activity of acridine derivatives and their analogues.
The second chapter deals with the aim of the work and schemes that had been carried out to obtain the new acridine derivatives and their analogues.
The third chapter clarifies the theoretical discussion of the experimental work concerning the preparation of 4-benzazolylanilines Ia-c and their acetyl derivatives IIa-c.
Condensation of Ia-c with o-chlorobenzoic acid gave IIIa-c which cyclized to IVa-c using polyphosphoric acid. Reacting VI with IIa-c yielded compounds VIIa-c, but esterification of VI gave VIII which reacted with hydrazine to afford the acid hydrazide IX that was reacted with aromatic aldehydes to yield compounds Xa-h. On the other hand, reaction of XI with different aromatic aldehydes gave the acridine analogues XIIa-h.
The fourth chapter consists of the experimental part of this work which contains the detailed procedures used for the synthesis of the starting compounds Ia-c and IIa-c. Also the methods of preparation of the intermediates IIIa-c, V, VI, VIII, IX and XI, were mentioned. In addition to the adopted methods for the synthesis of the target new acridine derivatives IVa-c, VIIa-c and Xa-h and acridine analogues XIIa-h were mentioned. The structure elucidation of the new compounds was supported by element analysis, IR, 1H NMR, 13C NMR in addition to mass spectral data. It also focused on the anticancer activity of all final synthesized compounds of newly synthesized derivatives compared with doxorubicin as a standard cytotoxic agent using three cell lines (colon cancer, liver cancer and breast cancer).
Compound Xh showed the highest in vitro cytotoxic activity against colon cancer cell line HCT-116 but compound Xb had the highest in vitro cytotoxic activity against liver cancer cell line HepG-2. Also compounds VIIa&b & Xh showed nearly the same activity as doxorubicin against breast cancer cell line MCF-7.