Ahmed Zakaria Abdelazem, Ph.D.

Basic Information 

          Lecturer at Biotechnology and Life Sciences Department
                               Phone : (+2) 01092100680
                               E-mail Address:  aznagi@psas.bsu.edu.eg

Background

Ahmed graduated with Bachelor degree of Pharmaceutical Sciences, at Faculty of Pharmacy, Assiut University (in 2002 with a degree of honor). Then, he got his Master’s degree in Pharmaceutical Medicinal Chemistry (June 2009), also from Assiut University, through a scholarship funded by Academy of Scientific Research and Technology. In February 2015, he was awarded the Ph.D. degree in Biological Chemistry, from Korea University of Science and Technology (UST), Korea, through a fully funded scholarship. In September 2015, he was appointed in this current job as a Lecturer at Biotechnology and Life Sciences Department. Since October 2017, he started a postdoctoral fellowship at Hanyang University, Korea.

Research interest 

His research interest is using chemistry to understand/solve biological issues. Therefore, he works in the design and synthesis of organic compounds of potential biological activity (such as: prodrugs, kinase inhibitors, antiproliferative agents, neuroprotective agents, and fluorogenic probes). 

Projects 

? Development of fluorogenic probes for the detection of carbapenemase producing bacteria (postdoctoral project).

?  Design, synthesis and biological evaluation of new aryl urea compounds of potential kinase inhibition activity, (50,000 EGP) funded from Beni-Suef University for competitive research project.

Publication 


               

• Mohammad M. Al-Sanea, Mohammed Safwan Ali Khan , Ahmed Z. Abdelazem, So Ha Lee, Mok Pooi Ling, Mohammed Gamal Mahmoud, Mohamed E. Shaker, Muhammad Afzal, Bahaa G. M. Youssif, Nesreen Nabil Omar. Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds. Molecules, 2018, 23, 297. 

• Ahmed Z. Abdelazem, Mohammad M. Al-Sanea, Hyun-Mee Park, So Ha Lee. Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and biological evaluation of their anti-proliferative effect on cancer cell lines. Bioorganic and Medicinal Chemistry Letters, 2016, 26, 1301–1304.

• Ahmed Z. Abdelazem, Mohammad M. Al-Sanea, Byung Sun Park, Hye Mi Park, Kyung Ho Yoo, Taebo Sim, Jong Bae Park, Seung-Hoon Lee, So Ha Lee. Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors. European Journal of Medicinal Chemistry, 2015, 90, 195-208.

• Ahmed Z. Abdel-Azeem, Atef A. Abdel-Hafez, Gamal S. El-Karamany, Hassan H. Farag. Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: Design, synthesis, pharmacological investigations and docking studies. Bioorganic and Medicinal Chemistry, 2009, 17, 3665–3670.