أ.د. مروة محمود أحمد خلف المنصب الأكاديمي: أستاذ الأدوية والسموم مناصب أخري: أستاذ ورئيس قسم الأدوية والسموم بكلية الصيدلة - جامعة بني سويف. الأتصال: marwa.khalaf@pharm.bsu.edu.eg الدرجات العلمية: 2014 دكتوراة في الأدوية والسموم كلية الصيدلة جامعة بني سويف مصر 2007 ماجيستير في الأدوية والسموم كلية الصيدلة جامعة القاهرة مصر 2001 بكالوريوس في العلوم الصيدلية كلية الصيدلة جامعة القاهرة مصر عنوان رسالة الماجستير: دراسات فارماكولوجية لوقاية الكلى من التسمم الناتج عن سيسبلاتين في الجرذان. PHARMACOLOGICAL STUDIES ON THE PROTECTION OF THE KIDNEY AGAINST CISPLATIN INDUCED NEPHROTOXICITY IN RATS عنوان رسالة الدكتوراه: دراسة دوائية للتفاعلات المحتمله بين أدوية مضاده لمرض السكري وبعض العناصر النادرة في حيوانات التجارب. PHARMACOLOGICAL STUDY OF THE POSSIBLE INTERACTIONS BETWEEN CERTAIN ANTIDIABETICS AND SOME TRACE ELEMENTS IN EXPERIMENTAL ANIMALS المهام التدريسية: Undergraduate Pharmacy Students: Medical terminology Physiology Basic Pharmacology Chemotherapy, hormones and anticancer drugs Biostatistics and Bioassay Toxicology Clinical pharmacology Drug interactions First aid Postgraduate Pharmacy Students: Pharmaceutical Statistics Pharmacometrics Pathophysiology Pharmacometrics Toxicometrics Experimental Pharmacology Clinical Pharmacology Clinical Therapeutics أبحاث مختارة: (2016) “Vitamin E mitigates cisplatin-induced nephrotoxicity due to reversalofoxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation”, Journal of Biochemical and Molecular Toxicology, 00: 1-9. (2017) “Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice”, Pharmaceutical Biology, 55(1): 766–774. (2017) “Ameliorative effects of sildenafil and/or febuxostat on doxorubicin-induced nephrotoxicity in rats”, European Journal of Pharmacology, 805: 118–124. (2017) “Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin-induced renal injury in rats”, Journal of Biochemical and Molecular Toxicology, 31(11). (2018) ” Resveratrol influences platinum pharmacokinetics: A novel mechanism in protection against cisplatin-induced nephrotoxicity”, Toxicology Letters, 290:73-82. (2018) “Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways”, Food and Chemical Toxicology, 116: 152-160. (2019). “The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity”, Biomedicine & Pharmacotherapy, 109: 47-56. (2019). “Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression”, Immunopharmacology and Immunotoxicology, 41(3): 403-412. (2019). “Nicorandil combats doxorubicin–induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway”, Chemico-Biological Interactions, 311: 108777. (2020), “Potential anti-inflammatory and immunomodulatory effects of carvacrol against ovalbumin-induced asthma in rats”, Life Sciences, 242: 117222. (2021), ‘’Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/ protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enhancer of activated B cells in lung cancer’’, Journal of Pharmacy and Pharmacology, 73(8):1080-1091. (2021). ‘’Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis’’, Journal of Food Biochemistry, 45(6):e13765. (2021). ‘’Neuroprotective role of camphor against ciprofloxacin induced depression in rats: modulation of Nrf-2 and TLR4’’, Immunopharmacology and Immunotoxicology, 43(3):309-318. (2021). ‘’Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence’’, Environmental Science and Pollution Research, 28(47):67593-67607. (2022). ‘’Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-tumor Activity’’, Current Molecular Pharmacology, 15(1):213-226 ‘’Ameliorate impacts of scopoletin against vancomycin-induced intoxication in rat model through modulation of Keap1-Nrf2/HO-1 and IκBα-P65 NF-κB/ P38 MAPK signaling pathways: Molecular study, molecular docking evidence and network pharmacology analysis’’, International Immunopharmacology, 102:108382. (2022). ‘’Empagliflozin attenuates Neurodegeneration through Antioxidant, Antiinflammatory, and Modulation of α-synuclein and Parkin Levels in Rotenone-Induced Parkinson’s Disease in Rats’’, Saudi Pharmaceutical Journal, 30(6):863-873. (2022). ‘’Leurieus quinquestriatus scorpion venom ameliorates adjuvant-induced arthritis in rats: Modulating JAK/STAT/RANKL signal transduction pathway’’, International Immunopharmacology, 108:108853. (2022). ‘’Novel therapeutic modalities target cell signaling of Renin‐Angiotensin system/NF‐κB‐induced cell cycle arrest and apoptosis in urethane‐induced lung cancer in mice: An in vivo study’’, Journal of Biochemical and Molecular Toxicology, 36(10): e23162. “Cerastes snake venom as a promising approach in the management of complete Freund’s adjuvant-induced rheumatoid arthritis in rats: Involvement of RANKL and JAK/STAT pathway”, Journal of Ethnopharmacology, 5:314:116577. (2023). ‘’A novel protective modality against rotenone-induced Parkinson’s disease: A pre-clinical study with dulaglutide’’, International Immunopharmacology, 119:110170. (2024). ‘’Investigating the tamoxifen/high-fat diet synergy: a promising paradigm for nonalcoholic steatohepatitis induction in a rat model’’, Naunyn-Schmiedeberg's Archives of Pharmacology, Online ahead of print. DOI: 10.1007/s00210-024-03192-7. (2024) ‘’The impact of PPAR-γ/Nrf-2/HO-1, NF-κB/IL-6/ Keap-1, and Bcl-2/caspase-3/ATG-5 pathways in mitigation of DOX-induced cardiotoxicity in an animal model: The potential cardioprotective role of oxyresveratrol and/or dapagliflozin’’, Food and Chemical Toxicology, DOI: 10.1016/j.fct.2024.114863 (2024). “Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats”. European Journal of Pharmacology, 5:984:177069. https://doi.org/10.1016/j.ejphar.2024.177069 ISSN: Online: 1879-0712 - Print: 0014-2999 (2025). “Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression”. Food and Chemical Toxicology, 26:200:115406. https://doi.org/10.1016/j.fct.2025.115406 ISSN: Online: 1878-1705 – Print: 1567-5769 (2025). “Levomilnacipran alleviates cyclophosphamide-induced hepatic dysfunction in male Wistar albino rats; emerging role of α-Klotho/TLR4/p38-MAPK/NF-κB p65 and caspase-3-driven apoptosis trajectories”. International Immunopharmacology, 16:152:114384. https://doi.org/10.1016/j.intimp.2025.114384 ISSN: Online:1878-1705 - Print: 1567-5769 (2025). “Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways”. Immunopharmacology and Immunotoxicology, 2025 Feb 27:1-18. Online ahead of print. DOI: 10.1080/08923973.2025.2469220(2025). “Repurposing bosentan as an anticancer agent: EGFR/ERK/c-Jun modulation inhibits NSCLC tumor growth”. Fundamental and Clinical Pharmacology, 2025 Feb; 39(1): e13052. DOI: 10.1111/fcp.13052. (2025). “Targeting EGFR/PI3K/AKT/mTOR and Bax/Bcl-2/caspase3 pathways with ivermectin mediates its anticancer effects against urethane-induced non-small cell lung cancer in BALB/c mice”. Tissue and Cell, 2025 Mar 22:95:102873. Online ahead of print. DOI: 10.1016/j.tice.2025.102873. (2025). “Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay”. Toxicology and Applied Pharmacology, 2025 May 7:500:117373. DOI: 10.1016/j.taap.2025.117373 روابط أخري: Researchgate Google Scholar ORCID