د. هاني أحمد مصطفي محمد عمر المنصب الأكاديمي: أستاذ مساعد بقسم الأدوية والسموم مناصب أخري: الأتصال: Hany.Omar@pharm.bsu.edu.eg الدرجات العلمية: ٢٠١٠ دكتوراة جامعة ولاية أوهايو الولايات المتحدة الأمريكية ٢٠٠٥ ماجيستير في الأدوية والسموم كلية الصيدلة جامعة القاهرة مصر ١٩٩٨ بكالوريوس في العلوم الصيدلية كلية الصيدلة جامعة القاهرة مصر المجالات البحثية: ١. الفارماكولوجى الجزيئ ٢. علاج السرطان المهام التدريسية: أبحاث مختارة: Ahmed H. Abdelazeema, Mohammed T. El-Saadi, Asmaa G. Safi El-Din, Hany A. Omar and Samir M. El-Moghazy. Design, Synthesis and Analgesic/Anti-inflammatory Evaluation of Novel Diarylthiazole and Diarylimidazole Derivatives Towards Selective COX-1 Inhibitors with Better Gastric Profile. Bioorganic & Medicinal Chemistry 2016 Nov 23. pii: S0968-0896(16)31070-7 Hany A. Omar, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. AlTel. OSU-2S/sorafenib synergistic antitumor combination against hepatocellular carcinoma: The role of PKCδ/p53. Frontiers in Pharmacology 2016 10.3389/fphar.2016.00463 Jui-Hsiang Hung, Chia-Yun Chen, Hany A. Omar, Kuo-Yuan Huang, Che-Chia Tsao, Chien-Chih, Chiu, Yi-Ling Chen, Po-Han Chen, Yen-Ni Teng. Reactive oxygen species mediate terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins. Environmental Toxicology, December 2016, 31(12):1888-98 Mai F.Tolba, Hany A. Omar, Samar S. Azab, Amani E. Khalifa, Ashraf B. Abdel-Naim, Sherif Z. Abdel-Rahman. Caffeic acid phenethyl ester: A review of its antioxidant, antimicrobial activities, protective effects against ischemia reperfusion injury and drug adverse reactions. Critical Reviews in Food Science and Nutrition, 2016 Oct 2;56(13):2183-90. Ahmed Abdelazeem, Yasser Mohamed, Ahmed Gouda, Hany Omar, Majed Al Robaian. Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis and Biological Screening. Australian Journal of Chemistry June, 2016, 69, 1277–1284 Hany A. Omar, Wafaa R. Mohamed, Hany H. Arab, El-Shaimaa A. Arafa. Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PLoS ONE, 2016 Mar 31;11(3):e0151649 Khaled R. Abdellatif, Phoebe F. Lamie, Hany A. Omar. 3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 Apr;31(2):318-24. Hany A. Omar, Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny, Hany H. Arab, Abdel Nasser. A. M. Elgendy. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacological Reports, 2015. Sep;68(2): 349–56 Samir A. Salama, Mohammad S. Al-Harbi, Mohamed S. Abdel-Bakky, Hany A. Omar. Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model. Biochimie, June 2015. 115, 203-211. Kuan-Han Lee*, Hany A. Omar*, Shu-Jing Wu, Pin-Shern Chen, Yu-Chung Chen, Yen-Ni Teng, Hung-Chang Huang, Clay C. C. Wang and Jui-Hsiang Hung. The effect of reactive oxygen species produced by 6-shogaol on cell cycle progression and cell death-associated signaling pathways in human hepatoma cells. European Journal of Pharmacology, June 2015, 762(5) 449–458. Hany H. Arab, Samir A. Salama, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS ONE, March, 2015, 30;10(3):e0122417. Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba. Design, Synthesis and Biological Evaluation of Novel Diphenylthiazole-Based Cyclooxygenase Inhibitors as Potential Anticancer Agents. Bioorganic Chemistry, Dec 2014, 57, 132–141. Hany A. Omar, Mai F. Tolba and Maha M. Saber-Ayad. Potential Targets of Energy Restriction Mimetic Agents in Cancer Cells. Future Oncology, 2014 Dec;10(16): 2547-2550. Khaled R. A. Abdellatif, Heba A. H. Elshemy, Samir A. Salama, and Hany A. Omar. Synthesis, characterization and biological evaluation of novel 4’-fluoro-2’-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, June 2015; 30(3):484-91. Ahmed H. Abdelazeem, Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar, Shabana I. Khan, Christopher R. McCurdy and Samir M. El-Moghazy. Novel Pyrazolopyrimidine Derivatives Targeting COXs and iNOS enzymes; Design, Synthesis and Biological Evaluation as Potential Anti-inflammatory Agents. European Journal of Pharmaceutical Sciences, Oct 2014, 62, 197–211. Hany H. Arab, Samir A. Salama, Ahmed H. Eid, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Camel’s milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Food and Chemical Toxicology, April, 2014, 69C:294-302. Hany A. Omar, El-Shaimaa A. Arafa, A. Maghrabi and Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-kB Signaling Inhibitor. Basic & Clinical Pharmacology & Toxicology, 2014 Jun;114(6):464-71. Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A. Omar, Po-Jui Huang, Clay C. C. Wang and Jui-Hsiang Hung. Modulation of cyclins, p53 and MAPK signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International Journal of Molecular Sciences, 2014, 15(1), 743-757. Samir A. Salama, Hany A. Omar, Ibrahim A. Maghrabi, Mohammed S. AlSaeed and Adel E. EL-Tarras. Iron supplementation at high altitude causes oxidative injury and inflammation in lung tissues of rats. Toxicology and Applied Pharmacology, 2014 Jan 1;274(1):1-6. El-Shaimaa A. Arafa, Ahmed H. Abdelazeem, Hany H. Arab and Hany A. Omar. OSU-CG5, a Novel Energy Restriction Mimetic Agent Inhibits Colorectal Cancer Cells. Acta Pharmacologica Sinica, 2014 Mar; 35(3):394-400. Samir A. Salama, Hany H. Arab, Hany A. Omar and Robert M. Snapka. Nicotine mediates hypochlorous Acid-induced nuclear protein damage in Mammalian cells. Inflammation, 2014 Jun;37(3):785-92. Hany A. Omar, El-Shaimaa A. Arafa, Samir A. Salama and Jing-Ru Weng. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology, 2013 Nov 1;272(3):616-24. Khaled R. A. Abdellatif a, Amany Belal, Hany A. Omar. Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues. Bioorganic & Medicinal Chemistry Letters, 2013 Sep 1;23(17):4960-4963 Mohamed A. Abdelgawad, Amany Belal, Hany A. Omar, Lamees Hegazy and Mostafa E. Rateb. Synthesis, Anti-Breast Cancer Activity and Molecular Modeling of Some Benzothiazole and Benzoxazole Derivatives. Archiv der Pharmazie Chemistry in Life Sci. 2013, 346(7), 534–541. Hany A. Omar, Samir A. Salama, El-Shaimaa A. Arafa and Jing-Ru Weng. Antitumor Effects of Energy Restriction-Mimetic Agents: Thiazolidinediones. Biological Chemistry, 2013; 394(7): 865–870. Ahmed O.H. El-Nezhawy, Ayman R. Biuomy, Fatma S. Hassan, Ayman K. Ismaiel and Hany A. Omar. Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. Bioorganic & Medicinal Chemistry, 2013 Apr 1;21(7):1661-1670. Hany A. Omar, Lisa Berman-Booty and Weng JR. Energy restriction: stepping stones towards cancer therapy. Future Oncology, 2012 Dec;8(12):1503-1506. Hany A. Omar, Yihui Ma, Jui-Hsiang Hung, Chih-Chien Chou, Lisa D. Berman-Booty, Dasheng Wang, Takayuki Kogure, Tushar Patel, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp and Ching-Shih Chen. Antitumor Effects of OSU-2S, a Non-immunosuppressive Analogue of FTY720, in Hepatocellular Carcinoma. Hepatology, 2011 Jun;53(6):1943-58. Hany A. Omar, Lisa Berman-Booty, Samuel K. Kulp, and Ching-Shih Chen. Energy Restriction as an Antitumor Target. Future Oncology, 2010 Nov; 6(11), 1675–1679. Jing-Ru Weng, Hany A. Omar, Samuel K. Kulp, and Ching-Shih Chen. Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents. Mini-Reviews in Medicinal Chemistry, 2010 May;10(5):398-404. Li-Yuan Bai, Hany A. Omar, Chang-Fang Chiu, Zeng-Pang Chi, Jing-Ru Weng. Antitumor effects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells. Cancer Chemotherapy and Pharmacology, 2010 Aug;68(2):489-96. Jing-Ru Weng, Li-Yuan Bai, Hany A. Omar, Aaron Sargeant , Ching-Tung Yeh, Yuan-Yin Chen, Ming-Hsui Tsai, Chang-Fang Chiu. A novel indole-3-carbinol derivative inhibits growth of human oral squamous cell carcinoma in vitro. Oral Oncology, 2010 Oct; 46(10): 748-754. Jing-Ru Weng, Chen-Hsun Tsai, Hany A. Omar, Aaron M. Sargeant, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen. OSU-A9, a Potent Indole-3-Carbinol Derivative, Suppresses Breast Tumor Growth by Targeting the Akt-NF-κB Pathway and Stress Response Signaling. Carcinogenesis, 2009 Oct;30(10):1702-9. Hany A. Omar, Aaron M. Sargeant, Jing-Ru Weng, Dasheng Wang, Samuel K. Kulp, Tushar Patel, and Ching-Shih Chen. Targeting of the Akt-NF-кB Signaling Network by OSU-A9, a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma. Molecular Pharmacology, 2009 Nov;76(5):957-68. مشاريع بحثية: روابط أخري: Linkedin Researchgate Google Scholar السيرة الذاتية