Research Article

Renal toxicity of titanium dioxide nanoparticlesin male albino rats

Abdou, Kh. A, walaa A. Moselhy, Hanaa M.Mohammed, El-Shaymaa El-Nahass and Ahlam G. Khalifa
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine – Beni-Suef University, Egypt

Abstract

Nanoparticles have many characteristics that make them suitable for biological and medical applications. Uptake of thesenano particulates into animals and humans bodiesthrough different routes may exhibit potential side effects. Titanium dioxide (TiO2) is a common additivethat is increasingly used in consumer products, food,pharmaceutical dosage forms and cosmetic articles. In this study, the effects of oral administration of TiO2 nanoparticles (500 mg| kg .bw) for 60 days were investigated on kidney function and histopathological changes. The body weight gain and kidney/body weight ratio showed no significant changes in comparison with control group. There was a significant decrease in total thiol levels in kidney homogenate, the biochemical changes was supported by histopathologicalultration. In conclusion the data shows that the oral administration of TiO2 NPs may lead to renal toxicity in experimental rats.

Keywords

Nanoparticle, oral toxicity, oxidative stress, Titanium dioxidenanoparticles, albino rat,nephrotoxicity